Impairments in frontal cortical γ synchrony and cognitive control in schizophrenia
Impairments in frontal cortical γ synchrony and cognitive control in schizophrenia
复制标题
DOI：
10.1073/pnas.0609440103
复制
发表时间：
2006-12-26
影响因子：
11.1
通讯作者：
Carter, C. S.
中科院分区：
文献类型：
--
作者：
Cho, R. Y.;Konecky, R. O.;Carter, C. S.
精神分裂症中认知障碍的一个关键组成部分可以被表征为认知控制的障碍，或者根据一个人的意图和目标灵活地指导和调整认知过程和行为的能力。精神分裂症的认知控制障碍一直与前额叶皮质功能的特定障碍有关，但其潜在的神经生理机制尚未得到很好的表征。同步伽马波段振荡已经与广泛的感知和认知过程相关联，提高了它们也可能有助于引导前额叶皮层回路为认知控制过程服务的可能性。在本研究中，我们测量了在一项任务，可靠地从事认知控制过程与前额叶皮层激活成像研究中诱导的γ-波段活动。我们发现，更高的认知控制需求与健康受试者的前额叶诱发γ-波段活动增加有关，但精神分裂症受试者的前额叶γ-波段活动的控制相关调制是不存在的。患者的γ-波段活动紊乱与疾病症状相关，对照组的γ-波段活动与表现呈正相关，但精神分裂症患者的γ-波段活动与表现无关。我们的研究结果可能提供了一个以前报道的死后异常丘脑额叶皮层电路和功能性神经影像学研究中观察到的前额叶活动的改变之间的联系。他们还认为额叶皮层γ-带同步性的缺陷可能导致精神分裂症的认知控制障碍。
A critical component of cognitive impairments in schizophrenia can be characterized as a disturbance in cognitive control, or the ability to guide and adjust cognitive processes and behavior flexibly in accordance with one's intentions and goals. Cognitive control impairments in schizophrenia are consistently linked to specific disturbances in prefrontal cortical functioning, but the underlying neurophysiologic mechanisms are not yet well characterized. Synchronous gamma-band oscillations have been associated with a wide range of perceptual and cognitive processes, raising the possibility that they may also help entrain prefrontal cortical circuits in the service of cognitive control processes. In the present study, we measured induced gamma-band activity during a task that reliably engages cognitive control processes in association with prefrontal cortical activations in imaging studies. We found that higher cognitive control demands were associated with increases in induced gamma-band activity in the prefrontal areas of healthy subjects but that control-related modulation of prefrontal gamma-band activity was absent in schizophrenia subjects. Disturbances in gamma-band activity in patients correlated with illness symptoms, and gamma-band activity correlated positively with performance in control subjects but not in schizophrenia patients. Our findings may provide a link between previously reported postmortem abnormalities in thalamofrontocortical circuitry and alterations in prefrontal activity observed in functional neuroimaging studies. They also suggest that deficits in frontal cortical gamma-band synchrony may contribute to the cognitive control impairments in schizophrenia.