Distinct mechanisms of modulation in a neuronal oscillator generate different social signals in the electric fish Hypopomus.
Distinct mechanisms of modulation in a neuronal oscillator generate different social signals in the electric fish Hypopomus.
复制标题
神经元振荡器的独特调节机制在电鱼 Hypopomus 中产生不同的社交信号。
DOI：
10.1007/bf00610872
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Heiligenberg,W
中科院分区：
文献类型：
--
作者：
Kawasaki,M;Heiligenberg,W
裸形电鱼（Hypopomus）的延髓起搏核是一个相对简单的神经元振荡器，含有起搏细胞和中继细胞。起搏细胞产生有规律的放电周期，并驱动中继细胞触发脉冲状电器官放电（EOD）。间脑起搏前核（PPN）投射到起搏核，并调节其活动，以产生各种特定的放电模式，这些放电模式作为通讯信号（图1A和1B）。在通过微离子电渗L-谷氨酸到箭毒动物的PPN区域（图4）来诱导这种信号的同时，我们在细胞内监测起搏核中神经元的活动。我们发现，起搏细胞和中继细胞以特定于EOD调制类型的方式受到不同的影响（图1和2）。5-10）。起搏细胞和中继细胞放电的正常顺序在放电率的逐渐上升和福尔斯下降过程中得以维持。这两种类型的电池在放电率下降后中断期间停止放电。然而，在突然中断期间，中继细胞稳定地去极化，而起搏细胞继续有规律地放电。短而快速的EODs的屏障，称为“啁啾”，通过直接和同步激活的中继细胞，其动作电位逆向侵入起搏细胞，并干扰他们的其他规则的放电模式。
The medullary pacemaker nucleus of the gymnotiform electric fish,Hypopomus, is a relatively simple neuronal oscillator which contains pacemaker cells and relay cells. The pacemaker cells generate a regular discharge cycle and drive the relay cells which trigger pulse-like electric organ discharges (EODs). The diencephalic prepacemaker nucleus (PPN) projects to the pacemaker nucleus and modulates its activity to generate a variety of specific discharge patterns which serve as communicatory signals (Figs. 2 and 3).While inducing such signals by microiontophoresis of L-glutamate to the region of the PPN (Fig. 4) of curarized animals, we monitored the activity of neurons in the pacemaker nucleus intracellularly. We found that pacemaker cells and relay cells were affected differently in a manner specific to the type of EOD modulation (Figs. 5–10). The normal sequence of pacemaker cell and relay cell firing was maintained during gradual rises and falls in discharge rate. Both types of cells ceased to fire during interruptions following a decline in discharge rate. During sudden interruptions, however, relay cells were steadily depolarized, while pacemaker cells continued to fire regularly. Short and rapid barrages of EODs, called “chirps”, were generated through direct and synchronous activation of the relay cells whose action potentials invaded pacemaker cells antidromically and interfered with their otherwise regular firing pattern.