Alterations in Brain Grey Matter Structures in Patients With Crohn's Disease and Their Correlation With Psychological Distress
Alterations in Brain Grey Matter Structures in Patients With Crohn's Disease and Their Correlation With Psychological Distress
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克罗恩病患者大脑灰质结构的改变及其与心理困扰的相关性。
DOI：
10.1093/ecco-jcc/jjv057
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发表时间：
2015-07-01
影响因子：
8
通讯作者：
Wu, Huan Gan
中科院分区：
文献类型：
--
作者：
Bao, Chun Hui;Liu, Peng;Wu, Huan Gan
背景：克罗恩病[CD]是否与脑结构改变相关尚不清楚。本研究探讨了乳糜泻患者脑灰质结构的变化及其与心理困扰的关系。方法：对45例CD患者和33例健康对照者进行磁共振成像（MRI）扫描。基于体素的形态测量和皮质厚度分析用于确定脑GM体积和皮质厚度。结果：CD患者的谷壳核、苍白球、丘脑、海马皮层、杏仁核、楔前叶、后顶叶皮层、导尿管周围灰质和小脑的GM体积显著升高，而其他皮质区域的GM体积均较低。CD患者脑岛、扣带皮层、海马旁皮层等皮层区域的皮质厚度均显著降低。在控制了心理困扰（焦虑和抑郁）后，涉及情绪处理的几个区域之间的差异并不显著。右前扣带皮层、背内侧前额叶皮层、左脑岛的GM体积、左脑岛和眶额皮质的皮质厚度与病程呈负相关。结论：我们认为，CD患者大脑多个区域GM结构的显著变化可以部分解释为这些患者更高水平的焦虑和抑郁。CD患者GM结构改变的特定特征与疾病持续时间相关。
Background: Whether Crohn's disease [CD] is correlated with brain structural changes is unclear. This study examined changes in grey matter [GM] structures in CD patients and their correlation with psychological distress.Methods: A total of 45 CD patients and 33 healthy controls were scanned using magnetic resonance imaging [MRI]. Voxel-based morphometry and a cortical thickness analysis were used to determine brain GM volume and cortical thickness.Results: The GM volumes in the CD patients were significantly higher in the putamen, pallidum, thalamus, hippocampal cortex, amygdala, precuneus, posterior parietal cortex, periaqueductal grey, and cerebellum, but were lower in many other cortical regions. The cortical thicknesses of the insula, cingulate cortex, parahippocampal cortex, and other cortical regions were significantly reduced in CD patients. After controlling for psychological distress [anxiety and depression], the differences among several regions involved in emotional processing were not significant. The GM volumes of the right anterior cingulate cortex, dorsomedial prefrontal cortex, and left insula and the cortical thickness of the left insula and orbitofrontal cortex were negatively correlated with disease duration.Conclusions: We suggest that the significant changes in GM structures in multiple brain regions of CD patients can be partially explained by the higher levels of anxiety and depression in these patients. Specific profiles of altered GM structures in CD patients were correlated with disease duration.