A maternal high-fat diet may accelerate adipo-immunologic aging in offspring
A maternal high-fat diet may accelerate adipo-immunologic aging in offspring
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DOI：
10.1016/j.lfs.2019.01.008
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发表时间：
2019-02-15
期刊：
影响因子：
6.1
通讯作者：
Sato, Kazuto
中科院分区：
文献类型：
--
作者：
Imai, Atsuko;Fujimoto, Eka;Sato, Kazuto
目的：母亲肥胖和营养不良易使后代患慢性代谢性疾病。虽然这些疾病的频率随着年龄的增长而增加，但母体高脂肪饮食对老年后代的影响仍然难以捉摸。主要方法：C57 BL/6 J雌性小鼠喂食高脂肪（HF）饮食或对照（CON）饮食，然后交配。所有后代与其出生母鼠在一起，直至3周断奶。断奶后，给予HF和CON饲料喂养的母鼠的后代HF饲料或CON饲料，这导致四个组：CON/CON、CON/HF、HF/CON和HF/HF。所有小鼠免疫卵清蛋白，然后在70 weeks.Key findings：暴露于HF饮食的母鼠的后代的体重显着高于在生命的早期阶段，但在生命的后期阶段，从母鼠喂养CON饮食的后代，然后变得较低。血清脂联素水平较低的后代从母鼠暴露于HF饮食，并与肥胖测量内脏和皮下脂肪量。非酒精性脂肪性肝病在母亲HF组的后代肝脏中更为严重。特别是，HF/HF组中小叶炎症和纤维化突出。关于免疫学参数，衰老相关的T细胞增加，自然杀伤T细胞减少的母亲和后代HF diet.Significance的影响：我们已经证明，母亲的高脂肪饮食可能会加速脂肪免疫衰老过程。
Aim: Maternal obesity and improper nutrition predispose offspring to chronic metabolic diseases. Although the frequency of these diseases increases with aging, the effect of a maternal high-fat diet on aged offspring remains elusive.Main methods: C57BL/6J female mice were fed a high-fat (HF) diet or a control (CON) diet and then mated. All offspring remained with their birth dam until weaning at 3 weeks. After weaning, the offspring from the HF and CON diet-fed dams were given either the HF diet or CON diet, which resulted in four groups: CON/CON, CON/HF, HF/CON, and HF/HF. All mice were immunized with ovalbumin and then sacrificed at 70 weeks.Key findings: The body weights in offspring from dam exposed to a HF diet were significantly higher than those in offspring from dam fed a CON diet in the early stage of life but then became lower in the later stage of life. The serum adiponectin levels were lower in offspring from dam exposed to a HF diet and were correlated with adiposity measured by visceral and subcutaneous fat mass. Non-alcoholic fatty liver disease was much more severe in the livers of offspring from the maternal HF groups. In particular, lobular inflammation and fibrosis were prominent in the HF/HF group. Regarding immunological parameters, senescence-associated T cells were increased, and natural killer T cells were decreased by the effect of both maternal and offspring HF diet.Significance: We have demonstrated that a maternal high-fat diet may accelerate the adipo-immunologic aging process.