Mapping the network for planning: a correlational PET activation study with the Tower of London task
Mapping the network for planning: a correlational PET activation study with the Tower of London task
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DOI：
10.1093/brain/122.10.1973
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发表时间：
1999-10-01
期刊：
影响因子：
14.5
通讯作者：
Brooks, DJ
中科院分区：
文献类型：
--
作者：
Dagher, A;Owen, AM;Brooks, DJ
我们使用伦敦塔任务（TOL）和（H2O）-O-15-PET来绘制参与计划的脑结构网络。6名健康右利手受试者在6种情况下进行了12次相对局部脑血流量（rrCBF）测量，每个测量两次。有一个休息条件，和五组不同复杂程度的TOL问题，用右臂在触摸敏感的计算机显示器上进行。复杂性被定义为解决每个问题所需的移动次数。激活进行了分析，在两种方式：类别分析比较水平的rrCBF在休息和任务，以确定所有的结构参与的性能的TOL;和相关性分析进行了描绘一个子集的结构，rrCBF的水平与任务的复杂性。rrCBF增加与复杂性无关的激活脑区可以分为：（i）属于视觉输入处理的背流的区域，即视觉皮层区17、18和19，以及后顶叶皮层区7和40;以及（ii）参与手臂运动的执行和排序的区域rrCBF水平与任务复杂性相关的脑区包括外侧运动前皮质（6区）、头端前扣带皮质（6区）、前扣带皮质（6区）和前扣带皮质（6区）。（32和24区），背外侧前额叶皮层（9区和46区）两侧，和右侧尾状背核，我们建议背外侧前额叶，外侧运动前区，前扣带和尾状区形成了一个网络，用于规划运动，该网络与主要参与视觉处理的大脑区域相互作用，动作执行。
We used the Tower of London task (TOL) and (H2O)-O-15-PET to map the network of brain structures involved in planning, Six healthy right-handed subjects had 12 measurements of relative regional cerebral blood flow (rrCBF) during six conditions, each performed twice. There was one rest condition, and five sets of TOL problems at different complexity levels, performed on a touch-sensitive computer monitor with the right arm, Complexity was defined as the number of moves required to solve each problem. Activation was analysed in two ways: a category analysis comparing levels of rrCBF during rest and task was done to identify all structures involved in performance of the TOL; and a correlation analysis was carried out to delineate a subset of structures where the levels of rrCBF correlated with task complexity. Activated brain areas in which rrCBF increases did not correlate with complexity could be grouped into: (i) regions belonging to the dorsal stream of visual input processing, namely visual cortical areas 17, 18 and 19, and posterior parietal cortical areas 7 and 40; and (ii) regions involved in the execution and sequencing of arm movements (right cerebellum, left primary motor cortex and supplementary motor area), Brain regions where levels of rrCBF correlated with task complexity included lateral premotor cortex (area 6), rostral anterior cingulate cortex (areas 32 and 24), dorsolateral prefrontal cortex (areas 9 and 46) bilaterally, and right dorsal caudate nucleus, We propose that dorsolateral prefrontal, lateral premotor, anterior cingulate and caudate areas form a network for the planning of movement that interacts with brain areas primarily involved in visual processing and movement execution.