QT-RR relationship in healthy subjects exhibits substantial intersubject variability and high intrasubject stability
QT-RR relationship in healthy subjects exhibits substantial intersubject variability and high intrasubject stability
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DOI：
10.1152/ajpheart.00860.2001
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发表时间：
2002-06-01
影响因子：
4.8
通讯作者：
Malik, M
中科院分区：
文献类型：
--
作者：
Batchvarov, VN;Ghuran, A;Malik, M
最近，有研究表明，QT-RR关系模式在健康个体之间存在显著差异。我们比较了QT-RR关系的个体内和个体间的差异。75例健康受试者(女性42例，男性33例，年龄27.9±9.6岁vs.26.8±7.5岁)分别于基线、24小时、1周、1月后每30名S记录一次10导联S心电(10导联)。用6种不同的算法自动测量每一次心电图的QT间期，并分析6种测量方法的平均值。在每个个体的每一次记录中，用10种不同的回归模型评估QT-RR关系，包括线性(Qt=β+αx RR)和抛物线(Qt=βx RRpha)模型。将每个个体连续记录的回归参数α和β的标准差(SD)与个体平均值的SD进行比较。用方差分析进一步检验受试者内的稳定性和个体间的变异性。在所有模型中，回归参数的个体内标准差均极显著小于个体均值的标准差(P
Recently, it was demonstrated that the QT-RR relationship pattern varies significantly among healthy individuals. We compared the intra- and interindividual variations of the QT-RR relationship. Twenty-four-hour 12-lead digital electrocardiograms (ECGs; SEER MC, GE Marquette; 10-s ECG recorded every 30 s) were obtained at baseline and after 24 h, 1 wk, and 1 mo in 75 healthy subjects (42 women, 33 men, age 27.9+/-9.6 vs. 26.8+/-7.5 yr, P=not significant). QT interval was measured automatically in each ECG by six different algorithms, and the mean of the six measurements was analyzed. In each recording of each individual, QT-RR relationship was assessed by 10 different regression models including linear (QT = beta + alpha x RR) and parabolic (QT = beta x RRalpha) models. Standard deviations (SDs) of regression parameters alpha and beta of consecutive recordings of each individual were compared with SD of the individual means. Intrasubject stability and interindividual variability were further tested by ANOVA. With all models, intraindividual SDs of the regression parameters were highly significantly smaller than SD of individual means (P