RESISTANCE TO A MALIGNANT-LYMPHOMA IN CHICKENS IS MAPPED TO SUBREGION OF MAJOR HISTOCOMPATIBILITY (B) COMPLEX
RESISTANCE TO A MALIGNANT-LYMPHOMA IN CHICKENS IS MAPPED TO SUBREGION OF MAJOR HISTOCOMPATIBILITY (B) COMPLEX
复制标题
DOI：
10.1126/science.6823560
复制
发表时间：
1983-01-01
期刊：
影响因子：
56.9
通讯作者：
STONE, HA
中科院分区：
文献类型：
--
作者：
BRILES, WE;BRILES, RW;STONE, HA
鸡的主要组织相容性(B)复合体中的基因重组揭示了影响对马立克S病(一种由疱疹病毒诱发的恶性淋巴瘤)的抗性的染色体亚区。BF21-G19是BF21-G21抗性单倍型杂合子和BF19-G19单倍型杂合子雄性后代中自发产生的重组子。分离重组子的家系对马立克氏病S病的暴露表明，这种新的F-G排列赋予了相当于抗性亲本单倍型的抗性水平。因此，在B复合体的B-F区域内或与B复合体的B-F区域紧密连锁的一个或多个基因似乎与观察到的对马立克氏‘’S病的抗性有关。
A genetic recombinant within the major histocompatibility (B) complex of the chicken has revealed the chromosomal subregion effecting resistance to Marek''s disease, a malignant lymphoma induced by a herpesvirus. The recombinant, BF21-G19, occurred spontaneously among the progeny of a male heterozygous for resistant BF21-G21 and susceptible BF19-G19 haplotypes. Exposure to Marek''s disease of families segregating for the recombinant showed that this new F-G arrangement conferred a level of resistance equivalent to that of the resistant parental haplotype. Thus, a gene, or genes, within or closely linked to the B-F region of the B complex appears to be responsible for the observed resistance to Marek''s disease.