PLASMID-MEDIATED RESISTANCE TO VANCOMYCIN AND TEICOPLANIN IN ENTEROCOCCUS-FAECIUM
PLASMID-MEDIATED RESISTANCE TO VANCOMYCIN AND TEICOPLANIN IN ENTEROCOCCUS-FAECIUM
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DOI：
10.1056/nejm198807213190307
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发表时间：
1988-07-21
影响因子：
158.5
通讯作者：
COURVALIN, P
中科院分区：
文献类型：
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作者：
LECLERCQ, R;DERLOT, E;COURVALIN, P
糖肽类抗生素万古霉素和替考拉宁可用于治疗革兰氏阳性菌引起的严重感染。123葡萄球菌、链球菌和肠球菌几乎总是对这些药物敏感，在出现耐药或不耐受的情况下，这些药物可替代青霉素。对糖肽类抗生素的耐药在明串珠菌属4和片球菌属中极为常见，也发生在乳酸杆菌中。5，6这些革兰氏阳性菌很少引起感染，被认为是机会致病菌。溶血性葡萄球菌菌株在万古霉素治疗过程中产生耐药性的现象最近已被证实。7链球菌对万古霉素的耐药性很少见。8肠球菌菌株具有最小的抑制作用。
THE glycopeptide antibiotic agents vancomycin and teicoplanin are useful in the treatment of severe infections due to gram-positive bacteria.123Staphylococci, streptococci, and enterococci are almost always susceptible to these agents, which constitute an alternative to the penicillins in cases of resistance or intolerance.Resistance to glycopeptides is extremely common in leuconostoc species4and pediococcus species and also occurs in lactobacilli.5,6These gram-positive bacteria rarely cause infections and are considered opportunistic pathogens. The emergence of strains ofStaphylococcus haemolyticusthat became resistant during vancomycin therapy has recently been reported.7Resistance to vancomycin is rare in streptococci.8Enterococcal isolates with minimal inhibitory . . .