Severe opioid toxicity and somatization of psychosocial distress in a cancer patient with a background of chemical dependence
Severe opioid toxicity and somatization of psychosocial distress in a cancer patient with a background of chemical dependence
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DOI：
10.1016/s0885-3924(97)00081-x
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发表时间：
1997-06-01
影响因子：
4.7
通讯作者：
Mitchell, S
中科院分区：
文献类型：
--
作者：
Lawlor, P;Walker, P;Mitchell, S
一名 52 岁的癌症患者描述了严重阿片类药物中毒的病例。患者表现出与阿片类药物毒性相关的中枢过度兴奋的典型临床特征：谵妄、肌阵挛、幻觉、痛觉过敏和可能的癫痫发作。该患者除了有苯二氮卓类药物依赖和酗酒史外，还有严重的社会心理困扰和躯体化背景。该患者发生的阿片类药物毒性凸显了单维方法治疗癌症疼痛的风险，这种方法忽视了疼痛的非器质性成分，例如社会心理困扰，而这种方法不会对阿片类药物剂量的增加产生反应。 (C) 美国癌症疼痛缓解委员会，1997 年。
A case of severe opioid toxicity is described in a 52-year-old cancer patient. The patient presented with classical clinical features of central hyperexcitability associated with opioid toxicity: delirium, myoclonus, hallucinations, hyperalgesia, and a possible seizure. This patient had a background of severe psychosocial distress and somatization in addition to a history of benzodiazepine dependence and alcohol abuse. The occurrence of opioid toxicity in this patient highlights the risks of a unidimensional approach to cancer pain, which ignores the non-organic components of pain, such as psychosocial distress, which will not respond to escalating doses of opioid medication. (C) U.S. Cancer Pain Relief Committee, 1997.