Dopamine-Based Coatings and Hydrogels: Toward Substitution-Related Structure-Property Relationships
Dopamine-Based Coatings and Hydrogels: Toward Substitution-Related Structure-Property Relationships
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DOI：
10.1002/macp.201400366
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发表时间：
2014-12-01
影响因子：
2.5
通讯作者：
del Campo, Arynzazu
中科院分区：
文献类型：
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作者：
Cui, Jiaxi;Iturri, Jagoba;del Campo, Arynzazu
研究了6-氯和6-硝基取代基对由多巴胺及其β-羟基衍生物去甲肾上腺素的可控氧化聚合产生的涂层的厚度、均匀性和一般性质的影响。在儿茶酚胺6-位的取代会影响沉积动力学，这是由于儿茶酚基团的氧化电位的改变。增加羟基酸性同样导致pH响应和水吸收的变化。在共价交联的儿茶酚官能化的PEG水凝胶中也观察到pH的类似趋势，而在金属交联的膜中测量到相反的行为。这些结果铺平了道路的定义的结构-性能关系的基础上多巴胺取代聚儿茶酚胺层和衍生聚合物的影响。
The influence of 6-chloro and 6-nitro substituents on the thickness, homogeneity, and general properties of coatings produced by controlled oxidative polymerization of dopamine and its beta-hydroxy derivative, norepinephrine, is investigated. Substitution at the catecholamine 6-position affects the deposition kinetics due to modification of the oxidation potential of the catechol groups. Increasing the hydroxyl group acidity results likewise in changes in pH response and water uptake. A similar trend with pH is also observed in covalently crosslinked catechol-functionalized PEG-hydrogels, while an opposite behavior is measured in metal crosslinked films. These results pave the way toward the definition of structure-property relationships based on dopamine substitution effects in polycatecholamine layers and derived polymers.