TOTAL SERUM-CHOLESTEROL AND CANCER MORTALITY IN A MIDDLE-AGED MALE-POPULATION
TOTAL SERUM-CHOLESTEROL AND CANCER MORTALITY IN A MIDDLE-AGED MALE-POPULATION
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DOI：
10.1093/oxfordjournals.aje.a113004
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发表时间：
1980-01-01
影响因子：
5
通讯作者：
RICHARD, J
中科院分区：
文献类型：
--
作者：
CAMBIEN, F;DUCIMETIERE, P;RICHARD, J
总胆固醇水平作为癌症死亡率的危险因素的评估来自巴黎冠心病前瞻性研究的数据。共有7603名年龄在43-52岁的法国男性政府雇员被跟踪调查，平均时间为6.6年；癌症死亡登记，平均生存时间为4.9。2.9年。在进入这项研究时，未来的癌症病例比幸存者年龄更大，肥胖指数更低，胆固醇值(212比223毫克/100毫升，SD=43毫克/100毫升)比幸存者更低。最初的胆固醇水平在不同的癌症部位没有显著差异。平均胆固醇值随着生存时间的延长而稳步增加(P<；0.02)，并在生存时间超过7年的男性中达到平均生存水平。81%的未来癌症病例的纵向胆固醇测量显示，平均3.0年后平均下降，与横断面数据估计的结果相当。在死亡前7年内，低胆固醇与癌症死亡率之间的联系可能不代表病因学上的联系，但可能反映了癌症临床病程的进展。
The assessment of total cholesterol level as a risk factor for cancer mortality was studied from data of the Paris Prospective Study of Coronary Heart Disease. A total of 7603 French male government employees aged 43-52 yr were followed for an average of 6.6 yr; cancer deaths were registered with a mean survival time of 4.9 .+-. 2.9 yr. At entry in the study, future cancer cases were older than survivors and had a lower corpulence index and lower cholesterol value (212 vs. 223 mg/100 ml. SD = 43 mg/100 ml) than those of survivors. The initial cholesterol level did not differ significantly among cancer sites. The mean cholesterol value increased steadily with survival time (P < 0.02) and reached the mean survivors level in men with survival time longer than 7 yr. Longitudinal cholesterol measurements obtained among 81% of future cancer cases showed a mean decrease after an average of 3.0 yr comparable to the one estimated from cross-sectional data. The association between low cholesterol and cancer mortality during a period up to 7 yr before death may not represent an etiologic link but probably reflects the advance of the clinical course of cancer.