Multiple measures of functionality exhibit progressive decline in a parallel, stochastic fashion in Drosophila Sod2 null mutants.
Multiple measures of functionality exhibit progressive decline in a parallel, stochastic fashion in Drosophila Sod2 null mutants.
复制标题
在果蝇 Sod2 无效突变体中，多种功能测量显示出以平行、随机方式进行性下降。
DOI：
10.1007/s10522-008-9210-2
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发表时间：
2009
期刊：
影响因子：
4.5
通讯作者：
Wessells,Robert
中科院分区：
文献类型：
--
作者：
Piazza,Nicole;Hayes,Michael;Martin,Ian;Duttaroy,Atanu;Grotewiel,Mike;Wessells,Robert
Oxidative damage has been proposed as an important factor in the progression of pathological and non-pathological age-related functional declines. Here, we examine functional deterioration in short-lived flies mutant for the mitochondrial antioxidantManganese Superoxide Dismutase(Sod2). We find that the decline of several functional measures of aging occurs, in an accelerated fashion, inSod2mutants. Olfactory behavior, locomotor ability and cardiac performance were all seen to decline rapidly inSod2mutants. On average, functional declines inSod2mutants occur in a pattern similar to that seen in late-lifeDrosophilawith a normal complement ofSod2. In longitudinal experiments, however, we find that functional failures occur in every possible sequence inSod2mutants. Significantly, failure of these functional measures is not irreversible, as spontaneous functional recovery was sometimes observed. These findings support a model where ROS-related damage strikes at multiple organ systems in parallel, rather than a “chain of dominos” model, in which primary organ failure contributes to the deterioration of further organ systems.
