OPTIMAL LOCAL PROPENSITIES FOR MODEL PROTEINS

OPTIMAL LOCAL PROPENSITIES FOR MODEL PROTEINS
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DOI：
10.1002/prot.340220411
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发表时间：
1995-08-01
期刊：
PROTEINS-STRUCTURE FUNCTION AND GENETICS
影响因子：
--
通讯作者：
GOLDSTEIN, RA
GOLDSTEIN, RA
中科院分区：
其他
文献类型：
--
作者：
GOVINDARAJAN, S;GOLDSTEIN, RA

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Lattice models of proteins were used to examine the role of local propensities in stabilizing the native state of a protein, using techniques drawn from spin-glass theory to characterize the free-energy landscapes, In the strong evolutionary limit, optimal conditions for folding are achieved when the contributions from local interactions to the stability of the native state is small, Further increasing the local interactions rapidly decreases the foldability. (C) 1995 Wiley-Liss, Inc.