Bio-inspired Domino oxa-Michael/Diels-Alder/oxa-Michael Dimerization of para -Quinols
Bio-inspired Domino oxa-Michael/Diels-Alder/oxa-Michael Dimerization of para -Quinols
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对喹啉的仿生 Domino oxa-Michael/Diels-Alder/oxa-Michael 二聚
DOI：
10.1002/ange.201802125
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发表时间：
2018
影响因子：
--
通讯作者：
Green N
中科院分区：
文献类型：
--
作者：
Green N
已经开发了生物启发的吡咯烷介导的对喹啉二聚化。它代表了有史以来最复杂但最普遍的二聚反应之一，选择性地形成四个新键，四个新环和八个新的连续立体中心。对苯二酚起始原料易于处理，是实验室稳定的化合物，只需一步即可从芳烃原料中获得。该反应可以按比例放大，得到克数的多环材料，为进一步的加工做好准备。
A bio‐inspired, pyrrolidine‐mediated, dimerization ofpara‐quinols has been developed. It represents one of the most complex, yet general, dimerization reactions ever disclosed, selectively forming four new bonds, four new rings, and eight new contiguous stereogenic centres. Thepara‐quinol starting materials are easily handled, bench‐stable compounds, accessed in just one step from aromatic feedstocks. The reaction can be scaled up to give grams of polycyclic material, primed for further elaboration.