Cadmium Is a Novel and Independent Risk Factor for Early Atherosclerosis Mechanisms and In Vivo Relevance
Cadmium Is a Novel and Independent Risk Factor for Early Atherosclerosis Mechanisms and In Vivo Relevance
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DOI：
10.1161/atvbaha.109.190082
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发表时间：
2009-09-01
影响因子：
8.7
通讯作者：
Bernhard, David
中科院分区：
文献类型：
--
作者：
Messner, Barbara;Knoflach, Michael;Bernhard, David
目的-虽然镉（Cd）是一种重要和常见的环境污染物，并已与心血管疾病，很少有人知道它的影响，在初始阶段的动脉粥样硬化。方法和结果-在195名年轻健康妇女的动脉粥样硬化危险因素在女性青年（ARFY）的研究，镉（Cd）水平与早期动脉粥样硬化血管壁增厚（内膜中层厚度超过分布的第90百分位数;多变量OR 1.6[1.1.- 2.3]，P=0.016）。与对照组相比，喂食镉的ApoE基因敲除小鼠的主动脉斑块表面显著增加（9.5对26.0 mm（2），P
Objectives-Although cadmium (Cd) is an important and common environmental pollutant and has been linked to cardiovascular diseases, little is known about its effects in initial stages of atherosclerosis.Methods and Results-In the 195 young healthy women of the Atherosclerosis Risk Factors in Female Youngsters (ARFY) study, cadmium (Cd) level was independently associated with early atherosclerotic vessel wall thickening (intima-media thickness exceeding the 90th percentile of the distribution; multivariable OR 1.6[1.1.-2.3], P=0.016). In line, Cd-fed ApoE knockout mice yielded a significantly increased aortic plaque surface compared to controls (9.5 versus 26.0 mm(2), P