Oxaliplatin-induced hyperexcitability syndrome in a patient with pancreatic cancer.
Oxaliplatin-induced hyperexcitability syndrome in a patient with pancreatic cancer.
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奥沙利铂诱发的胰腺癌患者过度兴奋综合征。
DOI：
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发表时间：
2009
期刊：
影响因子：
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通讯作者：
M. Saif
中科院分区：
文献类型：
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作者：
Hamid Saadati;M. Saif
最近的一项汇总分析和荟萃分析表明，与吉西他滨单药治疗胰腺癌相比，吉西他滨-铂双联治疗具有生存获益。感觉神经毒性是奥沙利铂治疗相关的潜在限制性毒性。在这封信中，我们描述了一例转移性胰腺癌患者在接受静脉奥沙利铂治疗时发生获得性神经性肌强直。它是一种以痉挛、肌肉抽搐、虚弱、肌强直和假性肌强直（用力收缩后肌肉松弛缓慢）为特征的病症。她的症状改善后，开始普瑞巴林。我们假设与奥沙利铂给药相关的过度兴奋综合征可以用普瑞巴林治疗。未来的研究将需要证实这一点，以及确定与普瑞巴林相关的长期不良反应。
A recent pooled analysis and a meta-analysis suggested a survival benefit of gemcitabine-platinum doublets when compared with single agent gemcitabine in pancreatic cancer. Sensory neurotoxicity is a potentially limiting toxicity associated with oxaliplatin therapy. In this letter, we describe a case of a patient with metastatic pancreatic cancer who developed acquired neuromyotonia while receiving intravenous oxaliplatin as part of her treatment. It is a condition characterized by cramps, muscle twitching, weakness, myotonia and pseudomyotonia (slow muscle relaxation after forceful contraction). Her symptoms were ameliorated after initiation of pregabalin. We postulate that hyperexcitability syndrome associated with administration of oxaliplatin can be treated with pregabalin. Future studies will be needed to confirm this as well as to determine the long-term adverse effects associated with pregabalin.