Tuberculosis: Time for a new perspective?
Tuberculosis: Time for a new perspective?
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DOI:
10.1016/j.jinf.2013.02.002
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发表时间:
2013-04-01
影响因子:
28.2
通讯作者:
Elkington, Paul T.
中科院分区:
文献类型:
--
作者:
Elkington, Paul T.
Transmission of Mycobacterium tuberculosis (Mtb) continues uninterrupted. Pre-exposure vaccination remains a central focus of tuberculosis research but 25 years of follow up is needed to determine whether a novel childhood vaccination regime protects from adult disease, or like BCG assists Mtb dissemination by preventing childhood illness but not infective adult pulmonary tuberculosis. Therefore, different strategies to interrupt the life cycle of Mtb need to be explored. This personal perspective discusses alternative approaches that may be delivered in a shorter time frame. (C) 2013 The British Infection Association. Published by Elsevier Ltd. All rights reserved.