Structure, Content, and Bioactivity of Food-Derived Peptides in the Body
Structure, Content, and Bioactivity of Food-Derived Peptides in the Body
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DOI：
10.1021/acs.jafc.8b00390
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发表时间：
2018-03-28
影响因子：
6.1
通讯作者：
Sato, Kenji
中科院分区：
文献类型：
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作者：
Sato, Kenji
口服给药的肽被认为在体内降解为氨基酸。然而，我们最近的研究发现，一些食物来源的脯氨酰和焦谷氨酰肽的2-3个氨基酸残基的人和动物的血液中，而大多数肽的内切蛋白酶消化的食物蛋白被外肽酶降解。一些食物来源的二肽在体内表现出体外和体内生物活性。这些事实表明，食物来源的肽在体内的生物活性，而不是那些在食物中是至关重要的了解口服给药的肽的有益作用的机制。
Orally administered peptides are assumed to be degraded into amino acids in the body. However, our recent studies revealed some food-derived prolyl and pyroglutamyl peptides with 2-3 amino acid residues in the blood of humans and animals, while most of the peptides in the endoproteinase digest of food protein are degraded by exopeptidase. Some food derived dipeptides in the body display in vitro and in vivo biological activities. These facts indicate that the biological activities of food-derived peptides in the body rather than those in food are crucial to understanding the mechanism of the beneficial effects of orally administered peptides.