Drinking despite health problems among individuals with liver disease across the United States
Drinking despite health problems among individuals with liver disease across the United States
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DOI：
10.1016/j.drugalcdep.2017.03.008
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发表时间：
2017-07-01
影响因子：
4.2
通讯作者：
Hasin, Deborah S.
中科院分区：
文献类型：
--
作者：
Elliott, Jennifer C.;Stohl, Malka;Hasin, Deborah S.
背景：大量饮酒对肝病患者有害。然而，这些人中的一些人尽管知道风险，但仍然喝酒。目前的研究旨在确定饮酒的因素，尽管个人与肝脏diseases.Methods的健康问题：目前的研究利用一个子样本的个人报告过去一年的肝脏疾病和至少一个饮料在过去的一年（n = 331），从全国流行病学调查酒精和相关条件-III（NESARC-III），一个大的全国代表性的调查美国。在一项横断面调查中，参与者报告了尽管存在健康问题、精神病理学症状和酒精问题家族史但仍饮酒的情况。药物使用病症（校正比值比[AOR] = 2.68），以及边缘型、反社会型和非典型人格障碍（AOR = 2.50-4.10），与肝病患者尽管存在健康问题但饮酒的可能性增加相关，所有ps < 0.05。任何焦虑障碍倾向于显著性（AOR = 2.22），p = 0.06，但重度抑郁障碍与风险增加无关（AOR = 0.99），ps = 0.97。有酒精问题家族史的个体也更有可能在健康问题的情况下饮酒（AOR = 2.79），p <0.05。结论：几种类型的精神病理学，以及酒精问题家族史，增加了肝病个体在健康问题的情况下饮酒的可能性。这些发现强调了对重度饮酒的肝病患者进行干预的必要性，这些患者可能因家族风险和/或共病精神病理学而饮酒。
Background: Heavy drinking is harmful for individuals with liver disease. However, some of these individuals drink despite knowledge of the risks. The current study aims to identify factors underlying drinking despite health problems among individuals with liver disease.Methods: The current study utilizes a subsample of individuals reporting past-year liver disease and at least one drink in the past year (n = 331), taken from the National Epidemiologic Survey on Alcohol and Related Conditions-III (NESARC-III), a large nationally representative survey of the United States. Participants reported on drinking despite health problems, symptoms of psychopathology, and family history of alcohol problems in a cross-sectional survey.Results: Drug use disorders (Adjusted Odds Ratio [AOR] = 2.68), as well as borderline, antisocial, and schizotypal personality disorders (AORs = 2.50-4.10), were associated with increased likelihood of drinking despite health problems among individuals with liver disease, all ps < 0.05. Any anxiety disorder trended toward significance (AOR = 2.22), p = 0.06, but major depressive disorder was not associated with increased risk, (AOR = 0.99), ps = 0.97. Individuals with a family history of alcohol problems were also more likely to drink despite health problems (AOR = 2.79), p < 0.05.Conclusions: Several types of psychopathology, as well as a family history of alcohol problems, increased the likelihood of drinking despite health problems among individuals with liver disease. These findings highlight the need to intervene with heavily drinking individuals with liver disease, who may be drinking due to familial risk and/or comorbid psychopathology.