Role of thyroid hormones in early postnatal development of skeletal muscle and its implications for undernutrition
Role of thyroid hormones in early postnatal development of skeletal muscle and its implications for undernutrition
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DOI：
10.1079/bjn19960091
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发表时间：
1996-12-01
影响因子：
3.6
通讯作者：
Dauncey, MJ
中科院分区：
文献类型：
--
作者：
Harrison, AP;Tivey, DR;Dauncey, MJ
能量摄入深刻地影响许多内分泌轴，而这些轴反过来又在发育中发挥核心作用。在一个大型哺乳动物在出生后早期的特定影响的短期轻度甲状腺功能减退症，类似于营养不良，在调节肌肉发育。通过在4至14日龄小猪的饲料中提供甲巯咪唑和碘番酸来诱导甲状腺功能减退症，并对对照组进行配对喂养，以补充甲状腺功能减退症同窝仔的能量摄入。评估甲状腺状态，然后在以下功能不同的肌肉中评估肌纤维分化和阳离子泵浓度：背最长肌（l.背肌）、比目鱼肌和菱形肌。血浆甲状腺素浓度降低（T-4; 32%，P
Energy intake profoundly influences many endocrine axes which in turn play a central role in development. The specific influence of a short period of mild hypothyroidism, similar to that induced by undernutrition, in regulating muscle development has been assessed in a large mammal during early postnatal life. Hypothyroidism was induced by providing methimazole and iopanoic acid in the feed of piglets between 4 and 14 d of age, and controls were pair-fed to the energy intake of their hypothyroid littermates. Thyroid status was evaluated, and myofibre differentiation and cation pump concentrations were then assessed in the following functionally distinct muscles: longissimus dorsi (l. dorsi), soleus and rhomboideus. Reductions in plasma concentrations of thyroxine (T-4; 32%, P