6. Asthma: Factors underlying inception, exacerbation, and disease progression.
6. Asthma: Factors underlying inception, exacerbation, and disease progression.
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DOI：
10.1016/j.jaci.2005.07.006
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发表时间：
2006-03
期刊：
影响因子：
--
通讯作者：
Busse WW
中科院分区：
文献类型：
--
作者：
Lemanske RF Jr;Busse WW
Asthma is a heterogeneous disorder that is characterized by variable airflow obstruction, airway inflammation and hyperresponsiveness, and reversibility either spontaneously or as a result of treatment. Multiple causes no doubt exist for both its inception and symptom exacerbation once the disease is established. Factors underlying inception can range from viral respiratory tract infections in infancy to occupational exposures in adults. Factors underlying asthma exacerbations include allergen exposure in sensitized individuals, viral infections, exercise, irritants, and ingestion of nonsteroidal anti-inflammatory agents among others. Exacerbating factors might include one or all of these exposures and vary both among and within patients. Asthma treatment is determined to a large extent after an assessment of severity, which can be variable over time and assessed in 2 domains: impairment (current) and risk (long-term consequences). Unfortunately, despite the availability of effective therapies, suboptimal asthma control exists in many patients on a worldwide basis. The future development of novel therapies and treatment paradigms should address these disparities.
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DOI：
10.1164/rccm.200407-894oc
发表时间：
2005-02-15
影响因子：
24.7
作者：
Bisgaard, H;Zielen, S;Polos, P
通讯作者：
Polos, P
DOI：
10.1016/j.cct.2004.03.002
发表时间：
2004-06-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
Guilbert, TW;Morgan, WJ;Martinez, FD
通讯作者：
Martinez, FD
影响因子：
14.2
作者：
Illi, S;von Mutius, E;Wahn, U
通讯作者：
Wahn, U
影响因子：
14.2
作者：
Bisgaard, H;Szefler, SJ
通讯作者：
Szefler, SJ
影响因子：
5.8
作者：
Gore, C;Custovic, A
通讯作者：
Custovic, A