Fish, ω-3 polyunsaturated fatty acids, and mortality from cardiovascular diseases in a nationwide community-based cohort of Japanese men and women -: The JACC (Japan Collaborative Cohort Study for Evaluation of Cancer Risk) study
Fish, ω-3 polyunsaturated fatty acids, and mortality from cardiovascular diseases in a nationwide community-based cohort of Japanese men and women -: The JACC (Japan Collaborative Cohort Study for Evaluation of Cancer Risk) study
复制标题
DOI：
10.1016/j.jacc.2008.06.018
复制
发表时间：
2008-09-16
影响因子：
24
通讯作者：
Tamakoshi, Akiko
中科院分区：
文献类型：
--
作者：
Yamagishi, Kazumasa;Iso, Hiroyasu;Tamakoshi, Akiko
目的本研究的目的是验证鱼或omega-3多不饱和脂肪酸(PUFA)摄入量与缺血性心脏病、心脏骤停、心力衰竭、中风和总心血管疾病死亡风险成反比的假设。亚洲社会中有关鱼和omega-3多不饱和脂肪酸饮食摄入量与心血管疾病风险关系的背景数据有限。通过食物频率问卷测定鱼和omega-3多不饱和脂肪酸的膳食摄入量，并对参与者进行了12.7年的跟踪调查。根据鱼类或omega-3多不饱和脂肪酸摄入量的五分位数计算危险比和95%可信区间。结果我们观察到鱼类和omega-3多不饱和脂肪酸摄入量与心力衰竭死亡风险总体呈负相关(最高和最低五分位数的多变量风险比[95%可信区间]=0.76[0.53至1.09]，omega-3 PUFA为0.58[0.36至0.93])。与缺血性心脏病或心肌梗死的相关性相对较弱，在调整潜在危险因素后没有统计学意义。鱼或omega-3多不饱和脂肪酸饮食摄入量与全卒中、其亚型或心脏骤停的死亡率均无关联。在总的心血管疾病死亡率方面，鱼和omega-3多不饱和脂肪酸的摄入量与风险降低18%-19%相关。结论鱼和omega-3多不饱和脂肪酸的饮食摄入量与心血管死亡率，特别是心力衰竭的死亡率呈负相关，提示鱼的摄入量对心血管疾病具有保护作用。
Objectives The objective of our study was to test the hypothesis that fish or omega-3 polyunsaturated fatty acids (PUFA) intakes would be inversely associated with risks of mortality from ischemic heart disease, cardiac arrest, heart failure, stroke, and total cardiovascular disease.Background Data on associations of dietary intake of fish and of omega-3 PUFA with risk of cardiovascular disease among Asian societies have been limited.Methods We conducted a prospective study consisting of 57,972 Japanese men and women. Dietary intakes of fish and omega-3 PUFA were determined by food frequency questionnaire, and participants were followed up for 12.7 years. Hazard ratios and 95% confidence intervals were calculated according to quintiles of fish or omega-3 PUFA intake.Results We observed generally inverse associations of fish and omega-3 PUFA intakes with risks of mortality from heart failure (multivariable hazard ratio [95% confidence interval] for highest versus lowest quintiles = 0.76 [0.53 to 1.09] for fish and 0.58 [0.36 to 0.93] for omega-3 PUFA). Associations with ischemic heart disease or myocardial infarction were relatively weak and not statistically significant after adjustment for potential risk factors. Neither fish nor omega-3 PUFA dietary intake was associated with mortality from total stroke, its subtypes, or cardiac arrest. For mortality from total cardiovascular disease, intakes of fish and omega-3 PUFA were associated with 18% to 19% lower risk.Conclusions We found an inverse association between fish and omega-3 PUFA dietary intakes and cardiovascular mortality, especially for heart failure, suggesting a protective effect of fish intake on cardiovascular diseases.