Efficacy and safety of Citrus sudachi peel in obese adults: A randomized, double-blind, pilot study
Efficacy and safety of Citrus sudachi peel in obese adults: A randomized, double-blind, pilot study
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DOI：
10.31989/ffhd.v4i7.5
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发表时间：
2014-07-01
影响因子：
1
通讯作者：
Sata, Masataka
中科院分区：
文献类型：
--
作者：
Akaike, Masashi;Aihara, Ken-ichi;Sata, Masataka
目的：本研究旨在探讨柑橘sudachi果皮对肥胖男性和女性成年人代谢危险因素的有效性和安全性。背景：柑橘sudachi Hort. ex Shirai（芸香科），又称“sudachi”，是一种小而圆的绿色柑橘类水果，主要种植于日本的德岛县。我们的小组报告说，柑橘sudachi果皮粉改善葡萄糖耐量和血脂异常的Zucher脂肪大鼠和降低高血糖和高甘油三酯血症的GK糖尿病rates.Materials和方法：我们进行了一项随机，双盲，安慰剂对照试验，在40名参与者腹部肥胖和代谢危险因素，包括高血压，糖耐量受损和甘油三酯水平升高。参与者被随机分配接受含有1.3克干柑橘果皮粉的片剂或安慰剂片剂，持续12周。Sudachi peel组包括14名男性和5名女性，平均年龄为54.5岁，安慰剂组包括18名男性和2名女性，平均年龄为51.9岁。结果：身体状况，包括体重，腰围和血压和实验室指标，包括代谢参数，在两组之间的任何观察点没有不同。然而，在血清甘油三酯水平超过120 mg/dl的参与者中，苏达皮组在治疗开始后的几个观察点体重、腰围和血清甘油三酯水平显着下降，但安慰剂组则没有。没有严重的不良事件，观察到在sudachi peel group.Conclusions：柑橘sudachi果皮有潜在的影响，以安全地改善腹型肥胖和降低血清甘油三酯水平的肥胖个体高血脂症。需要一项针对腹部肥胖和高TG水平受试者的大规模随机双盲临床研究来确认柑橘sudachi果皮的代谢作用。
Objective: This study was undertaken to explore the efficacy and safety of Citrus sudachi peel for metabolic risk factors in obese male and female adults.Background: Citrus sudachi Hort. ex Shirai ( Rutaceae), called "sudachi", is a small, round, green citrus fruit that is mainly cultivated in Tokushima Prefecture in Japan. Our group reported that Citrus sudachi peel powder improved glucose tolerance and dyslipidemia in Zucher-fatty rats and reduced hyperglycemia and hypertriglyceridemia in GK diabetic rats.Materials and Methods: We conducted a randomized, double-blind, placebo-controlled trial in 40 participants with abdominal obesity and metabolic risk factors including hypertension, impaired glucose tolerance and elevated triglyceride levels. Participants were randomized to receive either tablets that contained 1.3 g dried Citrus sudachi peel powder or placebo tablets for 12 weeks. The sudachi peel group included 14 males and 5 females with a mean age of 54.5 years, and the placebo group included 18 males and 2 females with a mean age of 51.9 years.Results: Physical status including body weight, waist circumference and blood pressure and laboratory markers including metabolic parameters were not different at any observation point between the two groups. However, among participants with serum triglyceride levels of more than 120 mg/dl, body weight, waist circumference and serum triglyceride levels were significantly decreased at several observation points after the start of treatment in the sudachi peel group but not in the placebo group. No serious adverse events were observed in the sudachi peel group.Conclusions: Citrus sudachi peel has the potential effect to safely improve abdominal obesity and lower serum levels of TG in obese individuals with hypertriglyceridemia. A large-scale randomized, double-blind clinical study targeting subjects with both abdominal obesity and high TG levels is needed to confirm the metabolic effects of Citrus sudachi peel.