Dietary treatment of irritable bowel syndrome
Dietary treatment of irritable bowel syndrome
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DOI：
10.1093/bmb/ldu039
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发表时间：
2015-03-01
影响因子：
6.7
通讯作者：
Akbar, A.
中科院分区：
文献类型：
--
作者：
Ahmad, O. F.;Akbar, A.
简介：食物是大多数肠易激综合征（IBS）患者公认的诱因。近年来，一个新兴的证据基础已经确定饮食控制是肠易激综合征的重要治疗方法。数据来源：通过在PubMed和谷歌Scholar上进行的选择性搜索确定了原始和评论文章。同意领域：随机对照试验支持使用限制一组短链碳水化合物的饮食，这些碳水化合物统称为可发酵低聚糖、双糖、单糖和多元醇（FODMAPs）。有证据表明，特定的益生菌可以改善肠易激综合征的症状。争议领域：高纤维饮食的作用仍在争论中，缺乏高质量的证据。低FODMAP饮食的长期持久性和安全性尚不清楚。生长点：一种范式的转变导致人们关注饮食与肠易激综合征病理生理机制之间的关系，如对肠道微生物群、炎症、运动性、渗透性和内脏超敏反应的影响。及时开展研究的领域：未来需要有严格终点的大型随机对照试验。此外，需要确定反应的预测因子以提供个性化治疗。
Introduction: Food is a recognized trigger for most patients with irritable bowel syndrome (IBS). In recent years, an emerging evidence base has identified dietary manipulation as an important therapeutic approach in IBS.Sources of data: Original and review articles were identified through selective searches performed on PubMed and Google Scholar.Areas of agreement: Randomized controlled trials have supported the use of a diet that restricts a group of short-chain carbohydrates known collectively as fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAPs). There is evidence that specific probiotics may improve symptoms in IBS.Areas of controversy: The role of a high-fibre diet remains subject to ongoing debate with a lack of high-quality evidence. The long-term durability and safety of a low FODMAP diet are unclear.Growing points: A paradigm shift has led to a focus on the relationship between diet and pathophysiological mechanisms in IBS such as effects on intestinal microbiota, inflammation, motility, permeability and visceral hypersensitivity.Areas timely for developing research: Future large, randomized controlled trials with rigorous end points are required. In addition, predictors of response need to be identified to offer personalized therapy.