Drug-Delivery Strategies by Using Template-Synthesized Nanotubes
Drug-Delivery Strategies by Using Template-Synthesized Nanotubes
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DOI：
10.1002/chem.201002835
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发表时间：
2011-05-01
影响因子：
4.3
通讯作者：
Stewart, Jon D.
中科院分区：
文献类型：
--
作者：
Perry, Jillian L.;Martin, Charles R.;Stewart, Jon D.
在中空纳米管中包裹药物有几个优点，包括防止降解，可能针对所需的位置，以及只有在特定条件下才能释放药物。模板合成利用氧化铝、聚碳酸酯或其他可在特定条件下溶解的材料制备的多孔膜。该方法可以很好地控制纳米管的长度和直径；此外，管可以由各种管材料构建，包括蛋白质、DNA、二氧化硅、碳和壳聚糖。已经开发了许多封顶策略来密封纳米管内的有效载荷。将这些进展与靶向纳米管并将其内化为活细胞的能力相结合，将使这些组件进入下一阶段的开发，即体内实验。
Encapsulating drugs within hollow nanotubes offers several advantages, including protection from degradation, the possibility of targeting desired locations, and drug release only under specific conditions. Template synthesis utilizes porous membranes prepared from alumina, polycarbonate, or other materials that can be dissolved under specific conditions. The method allows for great control over the lengths and diameters of nanotubes; moreover, tubes can be constructed from a wide variety of tube materials including proteins, DNA, silica, carbon, and chitosan. A number of capping strategies have been developed to seal payloads within nanotubes. Combining these advances with the ability to target and internalize nanotubes into living cells will allow these assemblies to move into the next phase of development, in vivo experiments.