Emotional modulation of pain: Is it the sensation or what we recall?
Emotional modulation of pain: Is it the sensation or what we recall?
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DOI：
10.1523/jneurosci.2260-06.2006
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发表时间：
2006-11-01
影响因子：
5.3
通讯作者：
Garcia-Larrea, Luis
中科院分区：
文献类型：
--
作者：
Godinho, Fabio;Magnin, Michel;Garcia-Larrea, Luis
情绪调节疼痛感知，尽管这种现象背后的机制尚不清楚。在这项研究中，我们表明，强度报告显着增加时，痛苦的刺激伴随着图像显示人类疼痛，而图片具有相同的情感价值，但没有躯体内容未能调节疼痛。早期躯体感觉反应（< 200 ms）不受情绪影响。相反，晚期反应显示与疼痛等级增加相关的显著增强，局限于右前额、右颞枕交界和右颞极。相反，选择性注意力，通过增加感官增益，提高疼痛评级，看到别人的痛苦所引发的情绪并没有改变在SI-SII（主要和第二躯体感觉区）的处理，但可能有偏见的转移，并在短期记忆缓冲区（前额叶）的疼痛表示，以及情感分配到这个表示（颞极）。记忆编码和回忆，而不是感觉处理，似乎是由对他人身体痛苦的同情来调节的。
Emotions modulate pain perception, although the mechanisms underlying this phenomenon remain unclear. In this study, we show that intensity reports significantly increased when painful stimuli were concomitant to images showing human pain, whereas pictures with identical emotional values but without somatic content failed to modulate pain. Early somatosensory responses (< 200 ms) remained unmodified by emotions. Conversely, late responses showed a significant enhancement associated with increased pain ratings, localized to the right prefrontal, right temporo-occipital junction, and right temporal pole. In contrast to selective attention, which enhances pain ratings by increasing sensory gain, emotions triggered by seeing other people's pain did not alter processing in SI-SII (primary and second somatosensory areas), but may have biased the transfer to, and the representation of pain in short-term memory buffers (pre-frontal), as well as the affective assignment to this representation (temporal pole). Memory encoding and recall, rather than sensory processing, appear to be modulated by empathy with others' physical suffering.