Antagonistic effects of atipamezole, flumazenil and 4-aminopyridine against anaesthesia with medetomidine, midazolam and ketamine combination in cats
Antagonistic effects of atipamezole, flumazenil and 4-aminopyridine against anaesthesia with medetomidine, midazolam and ketamine combination in cats
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DOI：
10.1016/j.jfms.2007.06.013
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发表时间：
2008-02-01
影响因子：
1.7
通讯作者：
Hikasa, Yoshiaki
中科院分区：
文献类型：
--
作者：
Ueoka, Naotami;Hikasa, Yoshiaki
在猫身上评估了单独使用阿替美唑 (ATI)、氟马西尼 (FLU) 和 4-氨基吡啶 (4AP) 以及不同组合在给予美托咪定-咪达唑仑-氯胺酮 (MED-MID-KET) 后的拮抗作用。肌肉注射MED(50μg/kg)、MID(0.5mg/kg)和KET(10mg/kg)麻醉动物。 20分钟后，静脉内给予生理盐水、ATI(200μg/kg)、FLU(0.1mg/kg)、4AP(0.5mg/kg)、ATI-FLU、FLU-4AP、ATI-4AP或ATI-FLU-4AP。 FLU、4AP单独使用或FLU-4AP均不能有效拮抗MED-MID-KET引起的麻醉、体温过低、心动过缓和呼吸缓慢。仅 ATI 就有效。 ATI-FLU、ATI-4AP 和 ATI-FLU-4AP 组合可立即有效地从麻醉中恢复。 ATI-FLU-4AP 组合在拮抗麻醉作用方面最有效，但与心动过速、呼吸急促、兴奋和肌肉震颤有关。与ATI联用拮抗麻醉效果更佳，但ATI-FLU-4AP不适用。 (c) 2007 ESFM 和 AAFR 由 Elsevier Ltd 出版。保留所有权利。
Antagonistic effects of atipamezole (ATI), flumazenil (FLU) and 4-aminopyridine (4AP) alone and in various combinations after administration of medetomidine-midazolam-ketamine (MED-MID-KET) were evaluated in cats. Animals were anaesthetised with MED (50 mu g/kg), MID (0.5 mg/kg) and KET (10 mg/kg) given intramuscularly. Twenty minutes later, physiological saline, ATI (200 mu g/kg), FLU (0.1 mg/kg), 4AP (0.5 mg/kg), ATI-FLU, FLU-4AP, ATI-4AP or ATI-FLU-4AP was administered intravenously. FLU, 4AP alone, or FLU-4AP did not effectively antagonise the anaesthesia, hypothermia, bradycardia, and bradypnoea induced by MED-MID-KET. ATI alone was effective. ATI-FLU, ATI-4AP and ATI-FLU-4AP combinations produced an immediate and effective recovery from anaesthesia. The combination of ATI-FLU-4AP was the most effective in antagonising the anaesthetic effects, but was associated with tachycardia, tachypnoea, excitement, and muscle tremors. Combinations with ATI are more effective for antagonising anaesthesia, but ATI-FLU-4AP is not suitable. (c) 2007 ESFM and AAFR Published by Elsevier Ltd. All rights reserved.