The effect of hyperbaric oxygen therapy on spinal fusion: Using the model of posterolateral intertransverse fusion in rabbits
The effect of hyperbaric oxygen therapy on spinal fusion: Using the model of posterolateral intertransverse fusion in rabbits
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DOI：
10.1097/00005373-200202000-00020
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发表时间：
2002-02-01
影响因子：
--
通讯作者：
Tai, CL
中科院分区：
文献类型：
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作者：
Chen, WJ;Lai, PL;Tai, CL
背景资料：本研究的目的是评估高压氧（HBO）对后外侧横突间融合的促进作用，使用一个经过验证的兔model.Methods：24只雄性新西兰兔进行后外侧横突间融合在L5-L 6自体髂骨移植。将他们平均分为两组：HBO组和正常室内空气（RA）组。每组分别于第4周和第8周处死6只家兔。高压氧组每天给予2.5atm的100%氧气2 h。结果：术后4、4、8、8周，横突间融合区影像学愈合分别为2/12、7/12、7/12、10/12。通过手动触诊证实的牢固愈合分别为6例中的0例、6例中的3例、6例中的4例和6例中的5例。平均峰值扭矩分别为2120.2、2576.5、2661.6和3079.8 N-mm。HBO组在4周和8周时脊柱融合率均显著提高。结论：与非HBO组相比，间歇性高压氧治疗可加速骨愈合过程，提高融合率。
Background: The purpose of this study is to evaluate the facilitating effect of hyperbaric oxygen (HBO) on posterolateral intertransverse fusion using a validated rabbit model.Methods: Twenty-four male New Zealand rabbits underwent posterolateral intertransverse fusion at L5-L6 with autogenous iliac bone graft. They were evenly divided into two groups: the HBO group and the normal room air (RA) group. Each group had six rabbits killed at 4 weeks and 8 weeks, respectively. The rabbits in the HBO groups were treated with 100% oxygen at 2.5 atm for 2 hours a day. After being killed, all rabbits were subjected to radiographic examination, manual testing, and torsional loading to evaluate the results of spinal fusion.Result: Radiographic union of intertransverse fusion areas at 4-week RA, 4-week HBO, 8-week RA, and 8-week HBO were 2 of 12, 7 of 12, 7 of 12, and 10 of 12, respectively. Solid union proven by manual palpation was found to be zero of six, three of six, four of six, and five of six of the cases, respectively. The average peak torsional momentums were 2120.2, 2576.5, 2661.6, and 3079.8 N-mm, respectively. Spinal fusion was significantly improved in the HBO groups at both 4 weeks and 8 weeks.Conclusion: The results of this study suggest that intermittent hyperbaric oxygen therapy will hasten the bone healing process and improve the fusion rate as compared with the non-HBO group.