Bioactive oxaphenalenone dimers from the fungus Talaromyces macrosporus KKU-1NK8
Bioactive oxaphenalenone dimers from the fungus Talaromyces macrosporus KKU-1NK8
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DOI：
10.1016/j.fitote.2019.03.015
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发表时间：
2019-04-01
期刊：
影响因子：
3.4
通讯作者：
Kanokmedhakul, Somdej
中科院分区：
文献类型：
--
作者：
Chaiyosang, Boonyanoot;Kanokmedhakul, Kwanjai;Kanokmedhakul, Somdej
从真菌TalaromycesmacrosporusKKU-1 NK 8的菌丝体中分离得到六个新的聚酮衍生的oxaphenalenone二聚体，talaromycesone C（1）和macrosporusone A-E（2-6），以及八个已知的类似物。根据光谱数据和质谱数据确定了它们的结构。新化合物1-6的绝对构型由ECD分析确定。化合物3和8对恶性疟原虫具有抗疟活性。化合物3显示出对NCI-H187细胞的活性，而化合物8显示出对KB、MCF-7和NCI-H187细胞系的活性。此外，化合物11对蜡状芽孢杆菌、金黄色葡萄球菌和MRSA表现出抗菌活性。
Six new polyketide-derived oxaphenalenone dimers, talaromycesone C (1) and macrosporusones A-E (2-6), together with eight known analogs, were isolated from the mycelium of the fungus Talaromyces macrosporus KKU-1NK8. Their structures were established based on their spectroscopic data and MS. The absolute configurations of new compounds 1-6 were determined by ECD analyses. Compounds 3 and 8 exhibited antimalarial activity against Plasmodium falciparum. Compound 3 showed activity against NCI-H187 cells, while compound 8 displayed activity against KB, MCF-7 and NCI-H187 cell lines. In addition, compound 11 showed antibacterial activity against Bacillus cereus, Staphylococcus aureus and MRSA.