Substance P and neurokinin-1 receptor modulation of HIV
Substance P and neurokinin-1 receptor modulation of HIV
复制标题
DOI：
10.1016/j.jneuroim.2004.08.022
复制
发表时间：
2004-12-01
影响因子：
3.3
通讯作者：
Douglas, SD
中科院分区：
文献类型：
--
作者：
Ho, WZ;Douglas, SD
在HIV感染者/AIDS患者中，生活事件应激、抑郁和相关症状的发生率很高。HIV和AIDS患者的心理和精神障碍可能与AIDS疾病的进展有关。抑郁、焦虑和压力与HIV疾病进展之间的相关性表明，神经生物学和神经生理学因素在调节HIV中具有重要作用。由行为状态或大脑活动的变化引起的免疫效应至少部分地通过神经内分泌免疫途径受到影响。生活压力和抑郁可能与CNS释放的神经肽（包括P物质（SP））的血液水平改变有关。SP是一种强有力的免疫调节剂，是神经系统和免疫系统之间的关键环节。我们研究了神经肽SP及其首选受体神经激肽-1在HIV感染和AIDS中的作用。有令人信服的数据，从我们的实验室，以及在文献中的发现，这表明，SP可能发挥重要作用的病理生理学的神经精神疾病，包括压力和抑郁症的HIV感染者和HIV疾病的免疫发病机制。调节SP活性和SP受体可能为治疗精神疾病和设计新的抗HIV疗法提供新的途径。(C)2004 Elsevier B. V.保留所有权利。
There is a high incidence of life event stress, depression, and associated symptoms in individuals with HIV infection/AIDS. Psychological and psychiatric symptomatology in individuals with HIV and AIDS may be related to the progression of AIDS disease. The association between depression, anxiety, and stress with HIV disease progression suggests that neurobiologic and neurophysiologic factors have an important role in modulating HIV. The immune effects caused by changes in behavioral state or brain activity are affected, at least in part, through the neuroendocrine-immune pathways. Life stress and depression may be associated with altered blood levels of CNS-released neuropeptides, including substance P (SP). SP is a powerful immunomodulator which is a critical link between the nervous and immune system. We have investigated the role of the neuropeptide SP and its preferred receptor, neurokinin-1, in HIV infection and AIDS. There are compelling data from our laboratories, as well as the findings in the literature, which demonstrate that SP may play an important role in the pathophysiology of neuropsychiatric disorders, including stress and depression in HIV-infected individuals and in the immunopathogenesis of HIV disease. Modulation of SP activity and SP receptor may offer a novel approach to the treatment of psychiatric disorders and to the design of new anti-HIV therapy. (C) 2004 Elsevier B.V. All rights reserved.