Nonspectroscopic interelement interferences in inductively coupled plasma mass spectrometry
Nonspectroscopic interelement interferences in inductively coupled plasma mass spectrometry
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DOI：
10.1021/ac00165a024
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发表时间：
1988-07
影响因子：
7.4
通讯作者：
G. Gillson;D. J. Douglas;J. Fulford;Kenneth Halligan;S. Tanner
中科院分区：
文献类型：
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作者：
G. Gillson;D. J. Douglas;J. Fulford;Kenneth Halligan;S. Tanner
先生：据报道，电感耦合等离子体质谱法（ICP-MS）相对于电感耦合等离子体发射光谱法（ICP-OES）更容易受到高浓度共存元素的非光谱元素间干扰（“基质效应”）（1-12）。Beauchemin et al. (3)总结了这些报告。在大多数情况下，分析物信号的抑制已经被报道，但在少数情况下（1，9）增强已经被看到。影响取决于ICP操作条件和透镜设置。不同的工人使用不同的条件，这可以解释不同行为的报告。然而，SCIEX（1-6）和VG（7-11）商业系统以及至少两种“自制”系统（2，12，13）报告了大致相似的影响。到目前为止，解释这些效应的机制主要集中在ICP或超音速膨胀上，尽管一些工作人员认为一些观察到的效应可能出现在电离光学中。在这篇文章中，我们将概述一种新的机制，这种机制似乎可以定性地解释许多不同的观察结果。该机制将明显的基质效应归因于离子束的通量和成分的变化。这些变化是由于空间电荷效应引起的。（尽管Olivares和Houk（14）指出空间电荷在ICP质谱仪的光学中可能很重要，但空间电荷和基质效应之间没有联系。离子电流测量和离子信号在检测器上的行为都为观察到的基质效应的起源提供了线索。离子电流的测量是由一个不锈钢收集器组成的三个同心环和一个中央圆形停止。(The收集器的总直径为4.5cm）。收藏家位于1。从掠行艇底部收集器的所有四个元素
Sir: It has generally been reported that inductively coupled plasma mass spectrometry (ICP-MS) is more susceptible to nonspectroscopic interelement interferences (“matrix effects”) by high concentrations of concomitant elements relative to inductively coupled plasma optical emission spectrometry (ICP-OES)(1-12). A recent paper by Beauchemin et al.(3) summarizes these reports. In most cases suppressions of analyte signalshave been reported, but in a few cases (1, 9) enhancements have been seen. The effects depend on both ICP operating conditions and lens settings. Different con-ditions have been used by various workers, which may explain reports of varied behavior. Nevertheless broadly similar effects have been reported for both SCIEX (1-6) and VG (7-11) commercial systems and for at least two “homemade” systems (2, 12, 13). The mechanisms proposed thus far to explain these effects have focused on the ICP or the supersonic expansion, although several workers have suggested that some of the observed effects may arise in the ionoptics. In this communication we will outline a new mechanism which qualitatively seems to account for many of the varied observations. The mechanism attributes the apparent matrix effects to changes in the flux and composition of the ion beam. These changes arise due to space charge effects within theskimmer.(Although Olivares and Houk (14) noted that space charge could be important in the optics of their ICP mass spectrometer, no connection between space charge and matrix effects was made.) Both ion current measurements and the behavior of ion signals at the detector provide clues as to theorigin of the matrix effectsobserved. Ion current measurements were made with a stainless steel collector consisting of three concentric rings and a central circular stop.(The overall diameter of the collector was 4.5 cm.) The collector was situated 1 in. from the base of the skimmer. All four elements of the collector