Twinning: Mechanisms and genetic implications
Twinning: Mechanisms and genetic implications
复制标题
DOI：
10.1016/s0959-437x(96)80012-8
复制
发表时间：
1996-06-01
影响因子：
4
通讯作者：
Hall, JG
中科院分区：
文献类型：
--
作者：
Hall, JG
过去，研究双胞胎是为了确定基因对各种疾病过程的影响。然而，最近的研究表明，同卵双胞胎（MZ）并不完全相同。许多遗传形式的不一致已经在MZ双胞胎中被描述，甚至可能在引起MZ双胞胎中起作用。子宫内环境在细胞数量分配和胎盘血管供应方面的差异，以及随机发育事件，可能导致MZ对双胞胎出生时的重大不一致。
in the past, twins have been studied to determine the genetic contribution to various disease processes. Recent work, however, suggests that monozygotic (MZ) twins are not truly identical. Many genetic forms of discordance have been described within MZ twin pairs and may even play a role in causing MZ twinning. Intra-uterine environmental differences in the allocation of the number of cells and in the placental vascular supply to each twin, as well as stochastic developmental events, may lead to major discordance at birth between the twins of a MZ pair.