Burden of fungal disease in Ireland
Burden of fungal disease in Ireland
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DOI：
10.1099/jmm.0.000020
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发表时间：
2015-04-01
影响因子：
3
通讯作者：
McMullan, Ronan
中科院分区：
文献类型：
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作者：
Dorgan, Eileen;Denning, David W.;McMullan, Ronan
我们的目标是估计真菌疾病的负担在爱尔兰岛，作为一个协调项目的一部分，估计全球负担。确定了描述爱尔兰真菌感染的已发表流行病学数据。收集了2010年的人群和基础疾病数据，并应用一组结构化假设，根据免疫抑制、慢性疾病和其他表明真菌感染易感性的人口统计学信息估计真菌疾病负担。从爱尔兰的640万人口中，我们估计每年有117000名患者患上严重的真菌病。到目前为止，最常见的真菌性疾病是复发性念珠菌阴道炎，估计每年有95 000例（每10万名妇女中有3000例）。其他可能不太清楚的真菌性疾病是严重哮喘伴真菌致敏和过敏性支气管肺曲霉病，估计每年的发病率分别为11700和9000（分别为182和140/100000人口）。该模型还估计了每年450例侵袭性曲霉病，200例慢性肺曲霉病，600例食管念珠菌病和450例念珠菌血症（每10万人口分别为7，3，9和6例）。我们认为，这是首次尝试估计真菌疾病在我们人群中的负担，并为估计其对人类健康和资源利用的影响提供了基础。
Our objective was to estimate the burden of fungal disease on the island of Ireland, as part of a coordinated project estimating the global burden. Published epidemiology data describing fungal infection in Ireland were identified. Population and underlying disease data were collected for 2010 and a structured set of assumptions were applied to estimate burden of fungal disease based on immunosuppression, chronic disease, and other demographic information indicating predisposition to fungal infection. From Ireland's population of 6.4 million, we estimate 117 000 patients develop significant fungal disease each year. By far the most common fungal disease is recurrent Candida vaginitis, with an estimated 95 000 episodes annually (3000 per 100 000 women). Other fungal diseases which may be less well recognized are severe asthma with fungal sensitization and allergic bronchopulmonary aspergillosis, with estimated episodes per year of 11 700 and 9000, respectively (182 and 140 per 100 000 population, respectively). The model also estimates 450 episodes of invasive aspergillosis, 200 of chronic pulmonary aspergillosis, 600 of oesophageal candidiasis and 450 of candidaemia per year (7, 3, 9 and 6 episodes per 100 000 population, respectively). This is, we believe, the first attempt to estimate the burden of fungal disease in our population and provides a basis for estimating its impact on human health and resource use.