An insertion/deletion variant of a thymine base in exon 2 of the porcine beta 3-adrenergic receptor gene associated with loin eye muscle area
An insertion/deletion variant of a thymine base in exon 2 of the porcine beta 3-adrenergic receptor gene associated with loin eye muscle area
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DOI：
10.1111/j.1740-0929.2009.00686.x
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发表时间：
2009-01-01
影响因子：
2
通讯作者：
Tanaka, Kazuaki
中科院分区：
文献类型：
--
作者：
Hirose, Kensuke;Nakamura, Mariko;Tanaka, Kazuaki
报道了猪β3-肾上腺素能受体(ADRB3)基因外显子2中胸腺嘧啶碱基(T5和T6)的插入/缺失变体。本研究对735头杜洛克猪ADRB3基因多态性与生产性能的相关性进行了研究。本研究人群中T5和T6等位基因频率分别为0.433和0.567。未发现ADRB3基因与试验期间平均日增重、背脂厚度和肌内脂肪含量之间的任何关联。然而，母猪的眼肌面积(EMA)大小与ADRB3基因型间存在显着的相关性。T6纯合子母猪的平均EMA(40.6+/-0.6cm2)显著高于T5纯合子母猪(38.1+/-0.4cm2，P=0.002)和杂合子母猪(38.8cm2+/-0.3cm2，P=0.034)。这种关联在男性中没有被检测到。此外，多性状动物模型最佳线性无偏预测(BLUP)分析表明，T6纯合子对EMA的育种值有正向影响。因此，我们认为ADRB3基因多态性有可能成为预测杜洛克猪EMA的一个重要遗传标记。
An insertion/deletion variant of a thymine base (T5 and T6) in exon 2 of porcine beta 3-adrenergic receptor (ADRB3) gene has been described. In the current study, we made an association study between the ADRB3 polymorphisms and production traits in 735 Duroc pigs. The allele frequencies for the T5 and T6 alleles in our study population were 0.433 and 0.567, respectively. Any associations between ADRB3 genotype and average daily weight gain during test period, or backfat thickness and intramuscular fat content were not detected in either sex. However the size of the loin eye muscle area (EMA) was significantly associated with ADRB3 genotypes in gilts. T6-homozygous gilts had a higher mean of EMA (40.6 +/- 0.6 cm2) than T5-homozygous (38.1 +/- 0.4 cm2, P = 0.002) and heterozygous (38.8 +/- 0.3 cm2, P = 0.034) gilts. This association was not detected in males. In addition, a multiple traits animal model best linear unbiased predictor (BLUP) analysis revealed that the T6-homozygous genotype had positive effects on breeding value of EMA. Accordingly, we suggest that ADRB3 polymorphism has the potential to be an important genetic marker for prediction of EMA in Duroc pigs.