Functional analysis of long terminal repeats derived from four strains of simian immunodeficiency virus SIVAGM in relation to other primate lentiviruses.
Functional analysis of long terminal repeats derived from four strains of simian immunodeficiency virus SIVAGM in relation to other primate lentiviruses.
复制标题
四种猿猴免疫缺陷病毒 SIVAGM 株衍生的长末端重复序列与其他灵长类慢病毒的功能分析。
DOI：
10.1016/0042-6822(91)90798-g
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发表时间：
1991
期刊：
影响因子：
3.7
通讯作者：
A. Adachi
中科院分区：
文献类型：
--
作者：
J. Sakuragi;M. Fukasawa;R. Shibata;H. Sakai;M. Kawamura;H. Akari;T. Kiyomasu;A. Ishimoto;M. Hayami;A. Adachi
The promoter activity of long terminal repeats (LTRs) of four strains of the simian immunodeficiency virus isolated from African green monkeys (SIVAGM) was compared with those of various LTRs derived from the other representative primate lentiviruses: human immunodeficiency virus type 1 (HIV-1), type 2 (HIV-2), SIV from a rhesus monkey (SIVMAC), and SIV from a mandrill (SIVMND). The expression of the LTRs was evaluated by monitoring chloramphenicol acetyltransferase production after transfection of reporter plasmid clones. In the absence of viral tat, all SIVAGMLTRs acted as much more efficient promoters than any of the other LTRs. Whentatgene products were supplied intrans, LTRs of SIVAGMand SIVMNDwer activated inefficiently relative ot high responder LTRs ov HIV-2 and SIVMAC. The LTR of HIV-1 was highly activated by HIV-1tat, but not so much by HIV-2, SIVAGM, and ISVMNDtat.
影响因子：
10.5
作者：
SELBY, MJ;BAIN, ES;PETERLIN, BM
通讯作者：
PETERLIN, BM