Sauropus androgynus L. Merr.-A phytochemical, pharmacological and toxicological review
Sauropus androgynus L. Merr.-A phytochemical, pharmacological and toxicological review
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Sauropus androgynus L. Merr.-植物化学、药理学和毒理学综述
DOI：
10.1016/j.jep.2020.112778
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发表时间：
2020
影响因子：
5.4
通讯作者：
Jie Zhang
中科院分区：
文献类型：
--
作者：
Bo-dou Zhang;Jia-xin Cheng;Chao-feng Zhang;Yi-dan Bai;Wen-yuan Liu;Wei Li;Kazuo Koike;Toshihiro Akihisa;Feng Feng;Jie Zhang
民族药理相关性研究Merr是一种未被开发的多年生灌木，传统上在南亚和东南亚用作药用植物。这种植物不仅被认为是一种绿色的饮食蔬菜，而且还是一种传统的草药，用于某些食物。例如，它传统上被用来解热，治疗溃疡和糖尿病，促进哺乳和视力，减轻肥胖。本研究的目的是综述雌雄同体的植物学、植物化学、民族药理学和药理活性，并讨论已知的化学成分在起作用。雌雄同体诱导的毛细支气管炎闭塞性支气管炎的发病机制和药理研究提供新的思路。材料和方法本综述中的数据来自已发表的文献以及PubMed、CNKI、Web of Science、SCI Finder、Science Direct、Wiley、Springer、Taylor、Google Scholar、和一些未出版的资源(如书籍、博士和硕士)。结果科学文献表明，雌雄同体是一种有价值的、广受欢迎的中草药，其营养价值也高于其他常用蔬菜。植物化学分析表明，其主要生物活性成分为脂肪酸、黄酮类和多酚。从雌雄同体植物中分离得到的粗提物和植物化学化合物显示出广泛的体外和体内药理活性，如抗氧化、抗炎、抗溃疡、皮肤美白、抗糖尿病和免疫调节活性。传统的用途，如增加哺乳，治疗溃疡和糖尿病，以及减少肥胖，已经用不同的方法进行了评估和研究。大量报道揭示了雌雄同体植物的消费与一种慢性不可逆转的阻塞性疾病(即闭塞性毛细支气管炎)的诱导之间的不同寻常的联系，表明这种目前用于医疗保健和医药的植物的毒性和副作用是一个主要的关注领域。结论虽然人们对这种绿色植物很少重视，但雌雄同体植物具有显著的植物化学成分和多种药理活性，包括抗氧化、抗炎和抗肥胖活性。研究已经确定了在一段时间内过量食用未煮过的雌雄同体果汁与发生闭塞性毛细支气管炎之间的联系。在充分了解这种致命疾病的发病机制和诱导机制之前，不宜摄入过量的OFS。雌雄同体的植物化学成分、其传统药理作用、雌雄同体诱导的毛细支气管炎闭塞性支气管炎仍需进一步研究。
Ethnopharmacological relevanceSauropus androgynusL. Merr is an underexploited perennial shrub traditionally used as a medicinal plant in South Asia and Southeast Asia. The plant is regarded as not just a green vegetable for diet, but as a traditional herb for certain aliments. For instance, it has traditionally been used to relieve fever, to treat ulcers and diabetes, to promote lactation and eyesight, and to reduce obesity.Aim of the studyThis paper aims to review the botany, phytochemistry, ethnopharmacology, and pharmacological activities ofS. androgynus, and discuss the known chemical constituents at work inS. androgynus-induced bronchiolitis obliterans for providing new ideas to the mechanism of the disease and pharmacology research of the plant.Materials and methodsThe data presented in this review were collected from published literatures as well as the electronic databases of PubMed, CNKI, Web of Science, SCI finder, ACS, Science Direct, Wiley, Springer, Taylor, Google Scholar, and a number of unpublished resources, (e.g. books, and Ph.D. and M.Sc. dissertations).ResultsThe scientific literature indicates thatS. androgynusis a valuable and popular herbal medicine whose nutritional value is also higher than that of other commonly used vegetables. Phytochemical analyses identified high content of fatty acids, flavonoids, and polyphenols as the major bioactive components inS. androgynus. Crude extracts and phytochemical compounds isolated fromS. androgynusshow a wide spectrum ofin vitroandin vivopharmacological activities such as antioxidant, anti-inflammatory, anti-ulcer, skin whitening, anti-diabetic, and immunoregulatory activities. The traditional use, such as increasing lactation, treating ulcers and diabetes, and reducing obesity, have been evaluated and studied with various methods. Numerous reports have revealed the unusual link between the consumption ofS. androgynusand the induction of a chronic and irreversible obstructive disease (namely, bronchiolitis obliterans), indicating that the toxicity and side effects of this plant that is presently used in health care and medicine are a major area of concern.ConclusionThough little importance was attached to this green plant,S. androgynushas notable phytochemical constituents and various pharmacological activities including antioxidant, anti-inflammatory, and anti-obesity activities. Studies have firmly established the association between excessive consumption of the uncookedS. androgynusjuice over a period of time and the occurrence of bronchiolitis obliterans. It is inadvisable to ingest excessive amounts ofS. androgynusbefore fully understanding the pathogenesis and induction mechanism of this fatal disease. The phytochemistry ofS. androgynus, its pharmacology for traditional use,S. androgynus-induced bronchiolitis obliterans still need further investigation.