14-3-3sigma, the double-edged sword of human cancers.
14-3-3sigma, the double-edged sword of human cancers.
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DOI：
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发表时间：
2009-06
影响因子：
2.2
通讯作者：
Zhaomin Li;Jing-Yuan Liu;Jian-Ting Zhang
中科院分区：
文献类型：
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作者：
Zhaomin Li;Jing-Yuan Liu;Jian-Ting Zhang
14-3-3sigma是一个高度保守的14-3-3蛋白家族的成员，存在于所有真核生物中。14-3-3 -3sigma被认为是一种肿瘤抑制因子，在某些人类癌症中表达减少，而其表达增加会导致对抗癌药物和辐射的抵抗，从而导致DNA损伤。14-3-3 -3sigma表达升高也可能预示某些人类癌症预后不良。因此，14-3-3sigma可能在人类癌症中发挥着重要的双刃剑作用，这可能是由于其作为分子伴侣的特性，通过结合各种蛋白质配体对许多细胞过程（如细胞周期检查点调节和细胞凋亡）在DNA损伤响应中发挥重要作用。在本文中，我们将回顾最近的研究和进展，了解14-3-3sigma作为人类癌症的双刃剑。
14-3-3sigma is a member of a highly conserved family of 14-3-3 proteins that are present in all eukaryotic organisms. 14-3-3sigma has been considered as a tumor suppressor with reduced expression in some human cancers while its increased expression causes resistance to anticancer agents and radiation that cause DNA damages. The increased expression of 14-3-3sigma may also predict poor prognosis in some human cancers. Thus, 14-3-3sigma may play an important role as a double-edged sword in human cancers, which may attribute to its property as a molecular chaperone by binding to various protein ligands important to many cellular processes such as cell cycle checkpoint regulation and apoptosis in response to DNA damages. In this article, we will review recent studies and progresses in understanding 14-3-3sigma as a double-edged sword in human cancers.