High-dose ifosfamide and mesna as continuous infusion over five days--a phase I/II trial.
High-dose ifosfamide and mesna as continuous infusion over five days--a phase I/II trial.
复制标题
高剂量异环磷酰胺和美司钠连续输注五天——I/II 期试验。
DOI：
10.1016/s0305-7372(83)80025-5
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发表时间：
1983
影响因子：
11.8
通讯作者：
N. Brock
中科院分区：
文献类型：
--
作者：
H. O. Klein;P. D. Wickramanayake;C. Coerper;E. Christian;J. Pohl;N. Brock
材料和方法大多数进入试验的患者患有常规化疗难治性肿瘤（表4）。38例患者入组本试验（Karnofsky范围：60-90%;中位年龄52岁）。IF与美司钠（剂量关系1：1，以mg/kg为基础）一起连续静脉给药5天。下议院。y剂量分成4个部分，每个部分在6小时内输注（图1）。起始剂量为60 mg] kg] 24 h× 5。在另外6名患者中测定了杀细胞代谢物4-羟基-异环磷酰胺的药代动力学和美司钠和活性硫醇化合物的尿排泄。通过Ellman（2）开发的改良方法，在405 nm处对游离巯基化合物和硫醇化合物（可通过还原二硫键检测）进行光度测定。采用荧光法测定4-羟基-异环磷酰胺（3）。
Materials and methodsMost patients entering the trial had tumours refractory to conventional chemotfierapy (Table 4). Thirty-eight patients were entered into this trial (Karnofsky range: 60-90%; median age 52 years). IF together with mesna (dose-relationship 1: 1 on a mg] kg basis) was administered iv continuously over 5 days. The dail. y dose was split into 4 fractions and each fraction was infused over 6 h (Figure 1). The starting dose was 60 mg] kg] 24 h× 5. In Table 1 the different doses of IF are listed and relate to the numffer of patients treated as well as to the treatment cycles.The pharmacokinetics of the cytocidal metabolite 4-hydl: oxy-ifosfamide and the urinary excretion of mesna and active thiol compounds were determined in a further 6 patients. The free sulfhydryl compounds and the thiol compounds, detectable by reduction of the bisulfide bonds, were assayed photometrically at 405 nm by a modified method developed by Ellman (2). 4-hydroxy-ifosfamide was determined fluorometrically (3).