MEASUREMENT OF EXTRA-VASCULAR LUNG WATER IN DOGS USING THE THERMAL-GREEN DYE INDICATOR DILUTION METHOD
MEASUREMENT OF EXTRA-VASCULAR LUNG WATER IN DOGS USING THE THERMAL-GREEN DYE INDICATOR DILUTION METHOD
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DOI：
10.1097/00000542-198208000-00009
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发表时间：
1982-01-01
期刊：
影响因子：
8.8
通讯作者：
LEWIS, F
中科院分区：
文献类型：
--
作者：
MIHM, FG;FEELEY, TW;LEWIS, F
在犬中评价了使用冷吲哚菁绿色染料通过双指示剂稀释技术测量血管外肺水。在11只动物中通过容量超负荷诱导肺水肿; 12只动物作为对照。对于每次测量，将2种指示剂（冷染料）注入上级腔静脉并在股动脉中检测。根据2条指示曲线的平均时间计算血管外热容量。肺血管外热容积（EVTV）与肺血管外组织重量（PEW）密切相关（EVTV = 1.15PEW +2.1ml/kg，n = 21，r = 0.97，P < 0.001）。在整个实验过程中，动脉氧分压和肺泡-动脉氧分压梯度与EVTV相关性较差（线性相关：r = 0.47，0.45，分别）。肺内分流与EVTV相关性较好（r = 0.72）。EVTV与血管内压力（左室充盈压、胶体充盈压和肺动脉闭塞压-胶体充盈压梯度）的非线性相关性较线性相关性更显著。在该模型中，肺水迅速增加的临界压力发生在左心室充盈压22-27 mm Hg和肺动脉闭塞压-胶体血管压力梯度25-30 mm Hg。热染料技术似乎提供了一个准确的测量肺水的变化，在这个高压水肿模型。
Measurement of extravascular lung water by a double-indicator dilution technique using cold indocyanine green dye was evaluated in dogs. Pulmonary edema was induced in 11 animals by volume overload; 12 animals served as controls. For each measurement, the 2 indicators (cold dye) were injected into the superior vena cava and detected in the femoral artery. The extravascular thermal volume was calculated from the mean times of the 2 indicator curves. Pretermination measurements of extravascular thermal volume [EVTV] correlated closely with standard gravimetric analysis of pulmonary extravascular tissue weight [PEW] (EVTV = 1.15 PEW + 2.1 ml/kg, n = 21, r = 0.97, P < 0.001). Throughout the experiment, the arterial O2 tension and alveolar-arterial O2 tension gradient correlated poorly with EVTV (linear correlation: r = 0.47, 0.45, respectively). The intrapulmonary shunt correlated better with EVTV (r = 0.72). Nonlinear correlation of EVTV with intravascular pressures (left ventricular filling pressures, colloid oncotic pressures and the pulmonary artery occlusion pressure-colloid oncotic pressure gradient) were more significant than linear relationships. The critical pressures at which lung water rapidly increased in this model occurred at left ventricular filling pressures of 22-27 mm Hg and at pulmonary artery occlusion pressure-colloid oncotic pressure gradients of 25-30 mm Hg. The thermal dye technique appears to provide an accurate measurement of lung water changes in this high pressure edema model.