CT-Based Characterization of Transverse and Longitudinal Trabeculae and Its Applications.
CT-Based Characterization of Transverse and Longitudinal Trabeculae and Its Applications.
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基于 CT 的横向和纵向小梁表征及其应用。
DOI：
10.1117/12.2549881
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Saha,PunamK
中科院分区：
文献类型：
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作者：
Zhang,Xiaoliu;Letuchy,ElenaM;Levy,StevenM;Torner,JamesC;Saha,PunamK
骨质疏松症是一种常见的年龄相关性疾病，其特征是骨密度(BMD)降低，微结构恶化，骨折风险增加。尽管骨密度在临床上被用来定义骨质疏松症，但有令人信服的证据表明，骨的微结构特性是骨强度和骨折风险的强有力的决定因素。有效的骨小梁微结构特征的可靠测量具有重要的临床意义。TB由横向和纵向两种微观结构组成，有一种假说认为，横向骨小梁通过阻止纵向骨小梁的屈曲来提高骨强度。在这篇文章中，我们提出了一种新的基于临床CT的新方法来表征横向和纵向小梁，验证了该方法，并考察了其在人体研究中的应用。具体地说，我们检查了重复CT扫描的重复性，并使用爱荷华州骨发育研究(IBDS)(n=99；49名女性)的人类CT数据评估了这些测量与性别和身体大小的关系。基于身体踝关节研究(n=12)，横向和纵向TB测量都被发现是可重复的(ICC<；0.94)。在IBDS人类数据中观察到，男性在内部(P<；0.05)和外部(P<；0.01)感兴趣区(ROI)的骨小梁测量值明显高于女性。对于体重，女性内部ROI指标的Spearman相关性为0.43-0.48，外部ROI指标为0.50-0.52，而男性为0.30-0.34和0.23-0.25。与身高的相关性较低(0.36-0.39)，但对女性的相关性最大。没有发现男性的骨小梁测量与身高有关。
Osteoporosis is a common age-related disease characterized by reduced bone mineral density (BMD), micro-structural deterioration, and enhanced fracture-risk. Although, BMD is clinically used to define osteoporosis, there are compelling evidences that bone micro-structural properties are strong determinants of bone strength and fracture-risk. Reliable measures of effective trabecular bone (Tb) micro-structural features are of paramount clinical significance. Tb consists of transverse and longitudinal micro-structures, and there is a hypothesis that transverse trabeculae improve bone strength by arresting buckling of longitudinal trabeculae. In this paper, we present an emerging clinical CT-based new method for characterizing transverse and longitudinal trabeculae, validate the method, and examine its application in human studies. Specifically, we examine repeat CT scan reproducibility, and evaluate the relationships of these measures with gender and body size using human CT data from the Iowa Bone Development Study (IBDS) (n = 99; 49 female). Based on a cadaveric ankle study (n = 12), both transverse and longitudinal Tb measures are found reproducible (ICC < 0.94). It was observed in the IBDS human data that males have significantly higher trabecular bone measures than females for both inner (p < 0.05) and outer (p < 0.01) regions of interest (ROIs). For weight, Spearman correlations ranged 0.43-0.48 for inner ROI measures and 0.50-0.52 for outer ROI measures for females versus 0.30-0.34 and 0.23-0.25 for males. Correlation with height was lower (0.36-0.39), but still mostly significant for females. No association of trabecular measures with height was found for males.