Metabolomics approaches in experimental allergic encephalomyelitis
Metabolomics approaches in experimental allergic encephalomyelitis
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DOI：
10.1016/j.jneuroim.2017.11.018
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发表时间：
2018-01-15
影响因子：
3.3
通讯作者：
Namer, I. J.
中科院分区：
文献类型：
--
作者：
Battini, S.;Bund, C.;Namer, I. J.
髓鞘碱性蛋白（MBP）诱导的实验性过敏性脑脊髓炎（EAE）涉及由于可逆性胸腰椎脊髓损伤所致的截瘫。因此，本研究的目的是寻找炎症的重要代谢生物标志物，并使用代谢组学鉴定疾病急性体征期间中枢神经系统（CNS）中的炎症部位。所有EAE样品均与较高水平的乳酸盐、抗坏血酸盐、葡萄糖和氨基酸相关，与对照组相比，N-乙酰-天冬氨酸（NAA）水平降低，尤其是腰髓中的NAA水平降低与临床体征相关。
A myelin basic protein (MBP)-induced experimental allergic encephalomyelitis (EAE) involves paraplegia due to a reversible thoracolumbar spinal cord impairment. The aims of this study were thus to find significant metabolic biomarkers of inflammation and identify the site of inflammation in the central nervous system (CNS) during the acute signs in of the disease using metabolomics.All the EAE samples were associated with higher levels of lactate, ascorbate, glucose and amino acids, and decreased level of N-acetyl-aspartate (NAA) compared to the control group.A decreased NAA level has been particularly shown in lumbar spinal cord in relationship with the clinical signs.