Most Small Cerebral Cortical Veins Demonstrate Significant Flow Pulsatility: A Human Phase Contrast MRI Study at 7T
Most Small Cerebral Cortical Veins Demonstrate Significant Flow Pulsatility: A Human Phase Contrast MRI Study at 7T
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DOI：
10.3389/fnins.2020.00415
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发表时间：
2020-05-05
影响因子：
4.3
通讯作者：
Wise, Richard G.
中科院分区：
文献类型：
--
作者：
Driver, Ian D.;Traat, Maarika;Wise, Richard G.
相位对比MRI（pcMRI）已被用于研究脑动脉、较大脑静脉和脑脊液（CSF）中的血流脉动性。颅内搏动性和顺应性的这种测量开始为理解包括正常压力脑积水、多发性硬化和痴呆在内的疾病的病理生理学提供信息。我们证明了小的大脑皮质静脉的流动脉动的存在下，第一次使用pcMRI在7 T，目的是提高我们的理解，这很少研究的血管室的血流动力学。介绍了一种建立静脉血流脉动的方法，在8名健康参与者的146条静脉中，有116条静脉显示出显著的脉动，在顶叶和额叶区域进行了评估。描述了搏动指数（PI）和脉搏波形延迟的分布，表明皮质静脉相对于上级矢状窦延迟59 +/- 41 ms，但差异较小，但具有统计学意义（p < 0.05），但引流不同动脉供血区的静脉之间无差异。在较小的皮质静脉，迄今未研究的隔间更接近毛细血管床的脉动性的测量，可以导致更好地了解颅内顺应性和脑血管（病理）生理。
Phase contrast MRI (pcMRI) has been used to investigate flow pulsatility in cerebral arteries, larger cerebral veins, and the cerebrospinal fluid (CSF). Such measurements of intracranial pulsatility and compliance are beginning to inform understanding of the pathophysiology of conditions including normal pressure hydrocephalus, multiple sclerosis, and dementias. We demonstrate the presence of flow pulsatility in small cerebral cortical veins, for the first time using pcMRI at 7 T, with the aim of improving our understanding of the hemodynamics of this little-studied vascular compartment. A method for establishing where venous flow is pulsatile is introduced, revealing significant pulsatility in 116 out of 146 veins, across eight healthy participants, assessed in parietal and frontal regions. Distributions of pulsatility index (PI) and pulse waveform delay were characterized, indicating a small, but statistically significant (p < 0.05), delay of 59 +/- 41 ms in cortical veins with respect to the superior sagittal sinus, but no differences between veins draining different arterial supply territories. Measurements of pulsatility in smaller cortical veins, a hitherto unstudied compartment closer to the capillary bed, could lead to a better understanding of intracranial compliance and cerebrovascular (patho)physiology.