Mutation of a histidine-rich calcium-binding-protein gene in wheat confers resistance to Fusarium head blight
Mutation of a histidine-rich calcium-binding-protein gene in wheat confers resistance to Fusarium head blight
复制标题
DOI：
10.1038/s41588-019-0426-7
复制
发表时间：
2019-07-01
期刊：
影响因子：
30.8
通讯作者：
Ma, Zhengqiang
中科院分区：
文献类型：
--
作者：
Li, Guoqiang;Zhou, Jiyang;Ma, Zhengqiang
主要由镰刀菌引起的头或耳疫病可摧毁几乎所有主要谷类作物（特别是小麦），造成巨大的经济损失，并对人类和牲畜的健康构成威胁（1-3）。然而，高抗性品种的选育成果仍不令人满意。本研究分离了小麦数量性状的主效位点Qfhs。njao - 3b，它具有抗头疫病的能力，并表明它与之前指定的Fhb1相同。Fhb1源于3BS染色体上富含组氨酸的钙结合蛋白基因的3'外显子的罕见缺失。经Fhb1序列转化的小麦和拟南芥对小麦镰刀菌的抗性增强。该基因的同源物在植物间的翻译产物保存较好，可能对植物的生长发育至关重要。Fhb1基因不仅可用于防治粮食作物赤霉病，还可用于改良其他易患赤霉病的植物。
Head or ear blight, mainly caused by Fusarium species, can devastate almost all staple cereal crops (particularly wheat), resulting in great economic loss and imposing health threats on both human beings and livestock(1-3). However, achievement in breeding for highly resistant cultivars is still not satisfactory. Here, we isolated the major-effect wheat quantitative trait locus, Qfhs.njau-3B, which confers head blight resistance, and showed that it is the same as the previously designated Fhb1. Fhb1 results from a rare deletion involving the 3' exon of the histidine-rich calcium-binding-protein gene on chromosome 3BS. Both wheat and Arabidopsis transformed with the Fhb1 sequence showed enhanced resistance to Fusarium graminearum spread. The translation products of this gene's homologs among plants are well conserved and might be essential for plant growth and development. Fhb1 could be useful not only for curbing Fusarium head blight in grain crops but also for improving other plants vulnerable to Fusarium species.