NASH and HCC
NASH and HCC
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DOI：
10.1016/j.cld.2009.07.007
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发表时间：
2009-11-01
影响因子：
5.1
通讯作者：
Harrison, Stephen A.
中科院分区：
文献类型：
--
作者：
Page, John M.;Harrison, Stephen A.
原发性肝癌是全球第五大常见恶性肿瘤，也是癌症死亡的第三大原因。非酒精性脂肪肝是美国慢性肝病最常见的原因，包括在没有大量饮酒的情况下以肝脂肪变性为标志的一系列实体。虽然单纯性脂肪变性通常是良性的，但更具侵袭性的非酒精性脂肪性肝炎可进展为肝硬化并导致包括肝细胞癌在内的并发症。相当数量的肝细胞癌病例仍然是隐源性的，没有已知的潜在慢性肝病。越来越多的人认识到，非酒精性脂肪性肝炎可能占隐源性肝细胞癌的很大一部分。
Primary liver cancer is the fifth most common malignancy worldwide and the third leading cause of cancer mortality. Non-alcoholic fatty liver disease is the most common cause of chronic liver disease in the United States encompassing a spectrum of entities marked by hepatic steatosis in the absence of significant alcohol consumption. Although simple steatosis follows a generally benign course, the more aggressive form, non-alcoholic steatohepatitis, can progress to cirrhosis and result in complications including hepatocellular carcinoma. A significant number of cases of hepatocellular carcinoma remain cryptogenic without known underlying chronic liver disease. It is increasingly recognized that non-alcoholic steatohepatitis likely accounts for a substantial portion of cryptogenic hepatocellular carcinoma.