Lessons from next generation influenza vaccines for inflammatory disease therapies.
Lessons from next generation influenza vaccines for inflammatory disease therapies.
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下一代流感疫苗用于炎症性疾病治疗的经验教训。
DOI：
10.1016/j.intimp.2019.105729
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发表时间：
2019
影响因子：
5.6
通讯作者：
Rosenthal,KenS
中科院分区：
文献类型：
--
作者：
Zimmerman,DanielH;Carambula,RoyE;Ciemielewski,Jason;Rosenthal,KenS
可以从开发通用流感疫苗的下一代方法中吸取治疗类风湿性关节炎 (RA) 等炎症性疾病的经验教训。炎症性疾病的免疫调节，而不是消除细胞因子或细胞反应，可以解决疾病的根本原因并提供潜在的治愈方法。与流感一样，每个人的疾病都有不同的抗原“毒株”和炎症 T 细胞反应（Th1 或 Th17）。因此，可以开发针对炎症性疾病的下一代疫苗样抗原特异性疗法，但需要根据导致疾病的抗原和 T 细胞反应针对患者进行定制。
Lessons can be learned for treating inflammatory diseases such as rheumatoid arthritis (RA) from next generation approaches for development of universal influenza vaccines. Immunomodulation of inflammatory diseases, rather than ablation of cytokine or cellular responses, can address the root cause of the disease and provide potential cure. Like influenza, there are different antigenic ‘strains’ and inflammatory T cell responses, Th1 or Th17, that drive each person's disease. As such, next generation vaccine-like antigen specific therapies for inflammatory diseases can be developed but will need to be customized to the patient depending upon the antigen and T cell response that is driving the disease.