Penetration of inhaled pollen into the respiratory tract.
Penetration of inhaled pollen into the respiratory tract.
复制标题
吸入的花粉渗入呼吸道。
DOI：
--
复制
发表时间：
2015
期刊：
影响因子：
--
通讯作者：
P. Cour
中科院分区：
文献类型：
--
作者：
F. Michel;J. Marty;L. Quet;P. Cour
花粉诱发哮喘的病理生理机制至今仍不清楚，因为花粉颗粒通常被认为太大而不能渗透到下呼吸道。因此，认为这种谷物不能诱导下呼吸道中的免疫应答。然而，颗粒渗透到呼吸道的实验曲线表明，一小部分大尺寸颗粒可能渗透到肺的外周区域。在我们的研究条件下，使用标记花粉粒的放射性同位素方法在检测预期在肺中发现的极少量颗粒方面无效。我们使用了另一种更简单、更有效的方法，该方法来自孢粉学家在检测沉积物中花粉粒时所使用的技术。根据我们的研究结果，这表明花粉粒通常存在于气管支气管分泌物和肺实质中，我们可以安全地假设吸入的花粉确实渗透到下呼吸道远端。目前，我们还不知道触发反应所需的花粉粒的精确数量，也不知道这些颗粒对小支气管和肺泡粘膜的影响。重要的是要确定这些颗粒是否对这些区域有影响，以及是否有直接机制参与花粉诱导的哮喘的发生。
The pathophysiologic mechanisms of pollen-induced asthma have heretofore remained unclear, because pollen particles have generally been considered too large to penetrate into the lower respiratory tract. Such grains are therefore believed to be unable to induce an immunologic response in the lower respiratory tract. Nevertheless, experimental curves of particle penetration into the respiratory tract indicate that a small percentage of large-sized particles may penetrate into the peripheral areas of the lungs. Under the conditions of our study, a radioisotopic method using labeled pollen grains was not effective in detecting the very small number of grains expected to be found in the lung. We used another simpler and more effective method derived from techniques used by palynologists in the detection of pollen grains in sediments. According to our results, which showed pollen grains normally present in tracheobronchial secretions and in lung parenchyma, we can safely assume that inhaled pollen does penetrate into the distal lower respiratory tract. At present, we do not know the precise number of pollen grains necessary to trigger a response, and we do not know the behavior of these grains with regard to the mucous membranes of the small bronchi and the alveoli. It is important to determine whether these grains have an effect on these areas and whether a direct mechanism is involved in the genesis of pollen-induced asthma.