Rhabdomyosarcoma
Rhabdomyosarcoma
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DOI：
10.1053/j.sempedsurg.2016.09.011
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发表时间：
2016-10-01
影响因子：
1.7
通讯作者：
Rodeberg, David
中科院分区：
文献类型：
--
作者：
Dasgupta, Roshni;Fuchs, Joerg;Rodeberg, David
横纹肌肉瘤(RMS)是一种儿童肿瘤，是一种起源于横纹肌的恶性肿瘤，经过近30年的综合治疗，总5年生存率达到70%。RMS的预后取决于原发肿瘤部位、年龄、切除的完全性、转移部位的存在和数量、肿瘤细胞的组织学和生物学。综合治疗是基于根据治疗前阶段、术后组、组织学和部位进行风险分层。RMS的独特之处在于术后临床分组的概念，它评估疾病切除的完整性，并考虑区域和转移盆地的淋巴评估。在所有部位，如果完成了疾病的完全手术切除，包括显微疾病，存活率就会提高。因此，外科医生在确定RMS患者的治疗风险分层、原发肿瘤的局部控制和总体结果方面起着至关重要的作用。(C)2016 Elsevier Inc.保留所有权利。
A malignant tumor of striated muscle origin, rhabdomyosarcoma (RMS) is a childhood tumor that has benefited from nearly 30 years of multimodality therapy, culminating in a >70% overall 5-year survival. Prognosis for RMS is dependent on primary tumor site, age, completeness of resection, presence and number of metastatic sites, histology, and biology of the tumor cells. Multimodality treatment is based on risk stratification according to pre-treatment stage, postoperative group, histology, and site. Unique to RMS is the concept of postoperative clinical grouping that assesses the completeness of disease resection and takes into account lymph node evaluation at both the regional and metastatic basins. At all sites, if complete operative resection of disease is accomplished, including microscopic disease, survival is improved. Therefore, the surgeon plays a vital role in determining risk stratification for treatment, local control of the primary tumor and overall outcome for the patient with RMS. (C) 2016 Elsevier Inc. All rights reserved.