Estimating liver perfusion from free-breathing continuously acquired dynamic gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid-enhanced acquisition with compressed sensing reconstruction.
Estimating liver perfusion from free-breathing continuously acquired dynamic gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid-enhanced acquisition with compressed sensing reconstruction.
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DOI：
10.1097/rli.0000000000000105
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发表时间：
2015-02
影响因子：
6.7
通讯作者：
Rusinek H
中科院分区：
文献类型：
--
作者：
Chandarana H;Block TK;Ream J;Mikheev A;Sigal SH;Otazo R;Rusinek H
在接受临床指征肝脏MRI的患者中，通过对连续采集的自由呼吸Gd-EOB-DTPA增强采集的高时间分辨率重建进行药代动力学建模，估计健康和肝硬化肝脏中的灌注指标。在这项符合HIPAA的前瞻性研究中，9名中风患者和10名非中风患者接受了临床MRI，其中包括在注射造影剂期间自由呼吸时连续采集的放射状星状堆叠3-D GRE序列和黄金角排序方案。在318 - 340秒内连续采集1904个径向轮辐。高时间分辨率数据集是通过对每帧13个轮辐进行分组形成的，时间分辨率为2.2 - 2.4秒，使用结合压缩感知和并行成像的GRASP（黄金角RAdial稀疏并行）技术重建。由委员会认证的放射科医师评价高时间分辨率重建，以生成主动脉（AIF）、门静脉（VIF）和肝脏中的钆浓度-时间曲线，将其拟合到双输入双室模型，以估计肝脏灌注指标;比较缺血和非缺血肝脏。肝硬化患者的总血浆流量显著降低（70.1 ± 10.1 vs 103.1 ± 24.3 ml/min/100 ml; p <0.05），门静脉血流量降低（33.4 ± 17.7 vs 89.9 ± 20.8 ml/min/100 ml; p <0.05），动脉灌注分数升高（52.0 ± 23.4 vs 12.4 ± 7.1%; p <0.05）。平均通过时间（MTT）在肝癌患者中较高（24.4 ± 4.7 vs 15.7 ± 3.4 sec; p <0.05），肝细胞摄取率（Ki）较低（3.03 ± 2.1 vs 6.53 ± 2.4/100/min; p <0.05）。肝脏灌注可以通过每次临床检查进行的自由呼吸动态采集来估计，无需额外的造影剂注射或时间。这是一种新的动态肝脏成像范例。
Estimating perfusion metrics in healthy and cirrhotic liver with pharmacokinetic modeling of high temporal resolution reconstruction of continuously acquired free-breathing Gd-EOB-DTPA enhanced acquisition in patients undergoing clinically indicated liver MRI. In this HIPAA compliant prospective study, nine cirrhotic and ten non-cirrhotic patients underwent clinical MRI which included continuously acquired radial stack-of-stars 3-D GRE sequence with golden-angle ordering scheme in free-breathing during contrast injection. 1904 radial spokes were acquired continuously in 318-340 seconds. High temporal resolution data sets were formed by grouping 13 spokes per frame for temporal resolution of 2.2-2.4 second, which were reconstructed using the GRASP (Golden-angle RAdial Sparse Parallel) technique that combines compressed sensing and parallel imaging. High temporal resolution reconstructions were evaluated by a board-certified radiologist to generate gadolinium concentration-time curves in the aorta (AIF), portal vein (VIF), and liver which were fitted to dual-input dual-compartment model to estimate liver perfusion metrics; which were compared between cirrhotic and non-cirrhotic livers. Cirrhotic livers had significantly lower total plasma flow (70.1±10.1 versus 103.1±24.3 ml/min/100ml; p< 0.05), lower portal venous flow (33.4±17.7 versus 89.9±20.8ml/min/100ml; p< 0.05), and higher arterial perfusion fraction (52.0± 23.4versus 12.4±7.1%; p<0.05). The mean transit time (MTT) was higher in cirrhotics (24.4±4.7 versus 15.7±3.4 sec; p<0.05), and hepatocellular uptake rate (Ki) was lower (3.03 ±2.1 versus 6.53± 2.4 /100/min; p<0.05). Liver perfusion can be estimated from free-breathing dynamic acquisition performed for every clinical exam without additional contrast injection or time. This is a novel paradigm for dynamic liver imaging.