GABA abnormalities in schizophrenia: a methodological review of in vivo studies.
GABA abnormalities in schizophrenia: a methodological review of in vivo studies.
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DOI：
10.1016/j.schres.2014.10.011
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发表时间：
2015-09
影响因子：
4.5
通讯作者：
Tso, Ivy F.
中科院分区：
文献类型：
--
作者：
Taylor, Stephan F.;Tso, Ivy F.
gaba能中间神经元的异常是精神分裂症死后研究中最一致的发现。然而，将这些分子缺陷与患者体内观察联系起来——这是评估针对gaba能缺陷的干预措施的关键目标——提出了一个挑战。在动物实验和精神分裂症患者实验文献的基础上建立了解释模型。这些文献包括：GABA受体的神经成像配体，GABA浓度的磁共振波谱（MRS），经颅磁刺激皮质抑制回路和GABA受体的药理学探针动态挑战GABA系统，通常与神经影像学研究相结合。药理学挑战已经引起了行为改变，并且已经进行了治疗性gaba能干预的初步研究。本文批判性地回顾了这些领域gaba能功能障碍的证据。这些方法仍然是gaba能功能的间接测量，广泛的功能障碍与假定的gaba能测量有关，包括阳性症状、认知、情绪、运动加工和感觉加工，涵盖不同的大脑区域。受体结合的测量并没有显示出可复制的组间差异，GABA浓度的MRS测定也产生了GABA浓度大规模改变的模棱两可的证据。总的来说，实验基础仍然很少，关于gaba能中间神经元在健康大脑中的作用还有很多有待了解。药理学和功能探针的挑战显示出希望，并且可能使精神分裂症中gaba能缺陷的更好表征成为可能。
Abnormalities of GABAergic interneurons are some of the most consistent findings from post-mortem studies of schizophrenia. However, linking these molecular deficits with in vivo observations in patients – a critical goal in order to evaluate interventions that would target GABAergic deficits – presents a challenge. Explanatory models have been developed based on animal work and the emerging experimental literature in schizophrenia patients. This literature includes: neuroimaging ligands to GABA receptors, magnetic resonance spectroscopy (MRS) of GABA concentration, transcranial magnetic stimulation of cortical inhibitory circuits and pharmacologic probes of GABA receptors to dynamically challenge the GABA system, usually in combination with neuroimaging studies. Pharmacologic challenges have elicited behavioral changes, and preliminary studies of therapeutic GABAergic interventions have been conducted. This article critically reviews the evidence for GABAergic dysfunction from each of these areas. These methods remain indirect measures of GABAergic function, and a broad array of dysfunction is linked with the putative GABAergic measures, including positive symptoms, cognition, emotion, motor processing and sensory processing, covering diverse brain areas. Measures of receptor binding have not shown replicable group differences in binding, and MRS assays of GABA concentration have yielded equivocal evidence of large-scale alteration in GABA concentration. Overall, the experimental base remains sparse, and much remains to be learned about the role of GABAergic interneurons in healthy brains. Challenges with pharmacologic and functional probes show promise, and may yet enable a better characterization of GABAergic deficits in schizophrenia.
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影响因子：
4.5
作者：
Fitzgerald, PB;Brown, TL;Kulkarni, J
通讯作者：
Kulkarni, J
影响因子：
5.5
作者：
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Ziemann, Ulf
影响因子：
10.6
作者：
Buchanan, Robert W.;Keefe, Richard S. E.;Lieberman, Jeffrey A.;Barch, Deanna M.;Csernansky, John G.;Goff, Donald C.;Gold, James M.;Green, Michael F.;Jarskog, L. Fredrik;Javitt, Daniel C.;Kimhy, David;Kraus, Michael S.;McEvoy, Joseph P.;Mesholam-Gately, Raquelle I.;Seidman, Larry J.;Ball, M. Patricia;McMahon, Robert P.;Kern, Robert S.;Robinson, James;Marder, Stephen R.
通讯作者：
Marder, Stephen R.
DOI：
10.1176/appi.ajp.2011.11010052
发表时间：
2011-09
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Curley AA;Arion D;Volk DW;Asafu-Adjei JK;Sampson AR;Fish KN;Lewis DA
通讯作者：
Lewis DA
影响因子：
4.5
作者：
Asai, Yoshiyuki;Takano, Akihiro;Suhara, Tetsuya
通讯作者：
Suhara, Tetsuya