Functionally different subpopulations of mouse macrophages recognized by monoclonal antibodies
Functionally different subpopulations of mouse macrophages recognized by monoclonal antibodies
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单克隆抗体识别的小鼠巨噬细胞功能不同的亚群
DOI：
10.1002/eji.1830120207
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发表时间：
1982
影响因子：
5.4
通讯作者：
M. Lohmann‐Matthes
中科院分区：
文献类型：
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作者：
Deming Sun And;M. Lohmann‐Matthes
描述了四种大鼠抗小鼠巨噬细胞单克隆抗体。其中三种对巨噬细胞高度特异，一种与粒细胞交叉反应。所有4种抗体均不与所有巨噬细胞共有的膜抗原反应，但与仅存在于20 - 50%细胞亚群上的抗原反应。所有抗体都对巨噬细胞具有直接或间接的细胞毒性。由这些抗体定义的亚群可以与某些巨噬细胞功能相关。因此，抗体M43消除了被淋巴因子激活而产生细胞毒性的巨噬细胞。抗体M43和M57消除杀死抗体包被的肿瘤靶点的巨噬细胞，克隆102（严格巨噬细胞特异性）消除自然杀伤细胞。只有M143与10 - 30%的巨噬细胞反应，尚未与任何功能相关。通过使用这些抗体，可以识别具有特定功能的巨噬细胞谱系的细胞并从给定的群体中消除。
Four rat anti‐mouse macrophage monoclonal antibodies are described. Three of them are highly specific for macrophages, and one cross‐reacts with granulocytes. All 4 antibodies do not react with membrane antigens shared by all macrophages, but with antigens present only on subpopulations of 20‐50% of the cells. All antibodies are directly or indirectly cytotoxic for macrophages. The subpopulations defined by these antibodies can be correlated with certain macrophage functions. Thus, antibody M43 eliminates macrophages that are activated by lymphokine to cytotoxicity. Antibodies M43 and M57 eliminate macrophages that kill antibody‐coated tumor targets, and clone 102 (strictly macrophage‐specific) eliminates natural killer cells. Only M143, reacting with 10‐30% of macrophages, has not yet been correlated with any function. With the use of these antibodies, cells of the macrophage lineage with specific functions can be recognized and eliminated from a given population.
大鼠抗小鼠吞噬细胞特异性单克隆抗体（抗 Mac-1）与人单核细胞和自然杀伤细胞的交叉反应。
DOI：
--
发表时间：
1981
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Ault,KA;Springer,TA
通讯作者：
Springer,TA